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alpha 2 Macroglobulin antibody [JM81-41]

Recombinant antibody
Anti-alpha 2 Macroglobulin antibody [JM81-41] used in Western Blot (WB). GTX01052
Anti-alpha 2 Macroglobulin antibody [JM81-41] used in IHC (Paraffin sections) (IHC-P). GTX01052
Anti-alpha 2 Macroglobulin antibody [JM81-41] used in IHC (Paraffin sections) (IHC-P). GTX01052
Anti-alpha 2 Macroglobulin antibody [JM81-41] used in IHC (Paraffin sections) (IHC-P). GTX01052

Cat No. GTX01052

Host

Rabbit

Clonality

Monoclonal

Clone Name

JM81-41

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μl ($369)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:1000-1:2000
IHC-P 1:50-1:200
Not tested in other applications.

Calculated MW

163 kDa. ( Note )

Observed MW

170~180 kDa. The observed M.W. is based on the following publication. PMID: 26103567

PROPERTIES

Form

Liquid

Buffer

1x TBS (pH7.4), 1% BSA, 40% glycerol, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

alpha-2-macroglobulin,A2M,A2MD,CPAMD5,FWP007,S8637,alpha2macroglobulin,alpha2 macroglobulin,alpha 2 Macroglobulin

Cellular Localization

Secreted

Background

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]

Database

  • Gene ID: 2 A2M
  • UniProt: P01023 A2M

Research Area

DATA IMAGES

Anti-alpha 2 Macroglobulin antibody [JM81-41] used in Western Blot (WB). GTX01052

GTX01052 WB Image

Human plasma (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with alpha 2 Macroglobulin antibody [JM81-41] (GTX01052) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
The observed M.W. is based on the publication: PMID: 26103567

Anti-alpha 2 Macroglobulin antibody [JM81-41] used in IHC (Paraffin sections) (IHC-P). GTX01052

GTX01052 IHC-P Image

IHC-P analysis of human liver tissue section using GTX01052 alpha 2 Macroglobulin antibody [JM81-41].

Anti-alpha 2 Macroglobulin antibody [JM81-41] used in IHC (Paraffin sections) (IHC-P). GTX01052

GTX01052 IHC-P Image

IHC-P analysis of human tonsil tissue section using GTX01052 alpha 2 Macroglobulin antibody [JM81-41].

Anti-alpha 2 Macroglobulin antibody [JM81-41] used in IHC (Paraffin sections) (IHC-P). GTX01052

GTX01052 IHC-P Image

IHC-P analysis of human spleen tissue section using GTX01052 alpha 2 Macroglobulin antibody [JM81-41].

REFERENCE

There are currently no references for alpha 2 Macroglobulin antibody [JM81-41] (GTX01052). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for alpha 2 Macroglobulin antibody [JM81-41] (GTX01052). Be the first to share your experience with this product.