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alpha Tubulin antibody [GT114]

Orthogonal
Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Anti-alpha Tubulin antibody [GT114] used in IHC (Frozen sections) (IHC-Fr). GTX628802
Anti-alpha Tubulin antibody [GT114] used in IHC (Paraffin sections) (IHC-P). GTX628802
Anti-alpha Tubulin antibody [GT114] used in IHC (Paraffin sections) (IHC-P). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Anti-alpha Tubulin antibody [GT114] used in IHC (Paraffin sections) (IHC-P). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

Cat No. GTX628802

Reference 122
21

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 GT114

Isotype

 IgG2a

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS

Reactivity

 Human, Mouse, Rat, Zebrafish, Drosophila
Package
100 μl ($379),
25 μl ($169)
See all alpha Tubulin products
PRODUCT

Summary

alpha Tubulin antibody [GT114] detects alpha Tubulin, a cytoskeletal protein widely expressed in cells that is commonly used as a loading control for western blots. The predicted molecular weight of alpha Tubulin protein is 50 kDa. This is a well-cited mouse monoclonal antibody validated for multiple applications including western blot, immunohistochemistry, and immunocytochemistry.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:20000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr 1:100-1:1000
FACS Assay dependent
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

Positive Control

293T , A431 , HeLa , HepG2 , NIH-3T3 , mouse brain , PC-12 , rat brain , drosophila , zebrafish eye , Neuro2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12 , *U87-MG

Predict Reactivity

Rabbit, Bovine, Pig, Xenopus laevis, Chimpanzee, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

1XPBS (pH7), 20% Glycerol

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human alpha Tubulin. The exact sequence is proprietary.

Purification

Affinity purified by Protein A.
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_2716636

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

K-ALPHA-1 antibody , TUBA1B antibody , alpha-tubulin ubiquitous antibody , alpha tubulin antibody , tubulin K-alpha-1 antibody , tubulin alpha-ubiquitous chain antibody , tubulin , alpha , ubiquitous antibody , tubulin alpha-1B chain antibody , tubulin , alpha 1b antibody

Background

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.

Research Area

DATA IMAGES

Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802

GTX628802 ICC/IF Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein expression by immunofluorescent analysis.
Sample: Cultured rat E18 primary cortical neuron, DIV 8. Cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: alpha Tubulin protein stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:250.
Red: NeuN, stained by NeuN antibody (GTX132974) diluted at 1:250.
Blue: Fluoroshield with DAPI (GTX30920).
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

GTX628802 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-alpha Tubulin antibody [GT114] used in IHC (Frozen sections) (IHC-Fr). GTX628802

GTX628802 IHC-Fr Image

Immunofluorescence photomicrographs of frozen sections of mouse brain.
Green: alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:200. The signal was developed using goat anti-rmouse IgG antibody (Dylight488) (GTX213111-04).
Blue: Nuclear staining with Hoechst 33342.
Anti-alpha Tubulin antibody [GT114] used in IHC (Paraffin sections) (IHC-P). GTX628802

GTX628802 IHC-P Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoplasm in human cervix by immunohistochemical analysis.
Sample: Paraffin-embedded human cervix.
alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-alpha Tubulin antibody [GT114] used in IHC (Paraffin sections) (IHC-P). GTX628802

GTX628802 IHC-P Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoplasm in mouse colon by immunohistochemical analysis.
Sample: Paraffin-embedded mouse colon.
Red: alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:500.
Green: beta Catenin antibody [N1N2-2] (GTX101435) diluted at 1:500.
Blue: Hoechst 33342 staining.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

GTX628802 WB Image

alpha Tubulin antibody detects alpha Tubulin protein by western blot analysis. Varied amount of 293T Whole cell extracts was separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody (GTX628802) at a dilution of 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-alpha Tubulin antibody [GT114] used in IHC (Paraffin sections) (IHC-P). GTX628802

GTX628802 IHC-P Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoplasm in human lung cancer by immunohistochemical analysis.
Sample: Paraffin-embedded human lung cancer.
alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

GTX628802 WB Image

alpha Tubulin antibody [GT114] detects TUBA1B protein by western blot analysis.
A. 30 μg zebrafish eye lysate/extract
10% SDS-PAGE
alpha Tubulin antibody [GT114] (GTX628802) dilution: 1:1000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802

GTX628802 ICC/IF Image

TUBA1B antibody detects TUBA1B protein at Cytoskeleton by immunofluorescent analysis.
Sample: HeLa cells were fixed in -20ºC 100% methanol for 5 min.
Green: TUBA1B protein stained by TUBA1B antibody (GTX628802) diluted at 1:500.
Blue: Hoechst 33342 staining.
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

GTX628802 WB Image

Whole cell extract (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

GTX628802 WB Image

alpha Tubulin antibody [GT114] detects TUBA1B protein by western blot analysis.
A. 30 μg 293T whole cell lysate/extract
B. 30 μg NIH-3T3 whole cell lysate/extract
C. 30 μg mouse brain lysate/extract
D. 30 μg PC-12 whole cell lysate/extract
E. 30 μg rat brain lysate/extract
F. 30 μg drosophila lysae/extract
10% SDS-PAGE
alpha Tubulin antibody [GT114] (GTX628802) dilution: 1:5000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

GTX628802 WB Image

Various whole cell extracts were separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802

GTX628802 ICC/IF Image

alpha Tubulin antibody [GT114] detects alpha Tubulin protein at cytoskeleton by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: alpha Tubulin stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:500.
Blue: Hoechst 33342 staining.
Scale bar= 10 μm.

Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802

GTX628802 WB Image

Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:10000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

REFERENCE

Application Reference

Ji-Xian Song et al. Bioengineered 2022; 13 (4) : 8334-8348 Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice.
Sophie Bachy et al. iScience 2022; 25 (2) : 103758 βig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer.
Mar?a Jos? Pe?a-G?mez et al. Int J Mol Sci 2022; 23 (2) XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxyuridine.
Eliot Gougeon et al. JFMS Open Rep 2022; 8 (1) : 20551169221081418 Myopathy with oval inclusions in a domestic shorthair cat.
Hung YH et al. Am J Cancer Res 2022; 12 (2) : 713-728 Semaphorin 4C promotes motility and immunosuppressive activity of cancer cells via CRMP3 and PD-L1.
Application : FACS
Reactivity : Human
Show More +
Submit a Reference

REVIEW

alpha Tubulin antibody [GT114] Cat No. GTX628802

Rating
( Average 4.9 based on 21 users reviews)
Application
Western Blot(WB)
( Average 5 based on 20 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 3 based on 1 users reviews)
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal ASN Neuro in 2013. PMID: 24286475
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Int J Mol Sci in 2020. PMID: 32150830
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Int J Mol Sci in 2020. PMID: 32150830
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Dm
Figure Note : The data was peer reviewed and published in the journal EMBO Mol Med in 2013. PMID: 23828861
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2013. PMID: 23977396
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal J Cell Mol Med in 2015. PMID: 25683605
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Curr Biol in 2017. PMID: 28966089
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2016. PMID: 27307030
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Int J Mol Sci in 2018. PMID: 29933620
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Biol Chem in 2016. PMID: 26742848
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Biol Chem in 2016. PMID: 26742848
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Zfsh
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2014. PMID: 25000307
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Cell Biosci in 2019. PMID: 31044068
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2020. PMID: 32005813
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal J Cell Mol Med in 2020. PMID: 31821701
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Toxins (Basel) in 2019. PMID: 31159487
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2015. PMID: 25811469
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2015. PMID: 25811469
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal J Cell Mol Med in 2020. PMID: 31821701
Anti-alpha Tubulin antibody [GT114] used in Western Blot (WB). GTX628802
Date : Anonymous submitted on 08-Jun-2017
Score :
Application Tested : WB
Sample Species : Hu
Sample : SW480 cells
Amount used : 40 μg
Blocking : 5% milk in TBST, 25°C, 1Hr
Primary Antibody : 1:20000, 4°C, 16Hr
Anti-alpha Tubulin antibody [GT114] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX628802
Date : Anonymous submitted on 24-Jun-2015
Score :
Application Tested : ICC/IF
Sample Species : Hu
Sample : U87-MG cells
Blocking : 5% BSA in PBST, 25°C, 2Hr
Fixation : 4% PFA
Primary Antibody : 1:200, 4°C, 16Hr
Show More +
Submit a Review
Application Reference
Ji-Xian Song et al. Bioengineered 2022; 13 (4):8334-8348 Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice.
Sophie Bachy et al. iScience 2022; 25 (2):103758 βig-h3-structured collagen alters macrophage phenotype and function in pancreatic cancer.
Mar?a Jos? Pe?a-G?mez et al. Int J Mol Sci 2022; 23 (2) XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxyuridine.
Eliot Gougeon et al. JFMS Open Rep 2022; 8 (1):20551169221081418 Myopathy with oval inclusions in a domestic shorthair cat.
Song JX et al. Pharm Biol 2022; 60 (1):609-620 Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Application : WB
Reactivity : Mouse
Hung YH et al. Am J Cancer Res 2022; 12 (2):713-728 Semaphorin 4C promotes motility and immunosuppressive activity of cancer cells via CRMP3 and PD-L1.
Application : FACS
Reactivity : Human
Huang WY et al. J Neuroinflammation 2022; 19 (1):29 TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation.
Application : WB
Reactivity : Mouse
Lu H.A. et al. Circ Res. 2022; 130 (1):112-129 Alternative Splicing Mediated by RNA-Binding Protein RBM24 Facilitates Cardiac Myofibrillogenesis in a Differentiation Stage-Specific Manner.
Application : WB, ICC/IF
Reactivity : Human
Li Y et al. Bioengineered 2022; 13 (1):800-809 Sitagliptin ameliorates hypoxia-induced damages in endometrial stromal cells: an implication in endometriosis.
Application : WB
Reactivity : Human
Gaetana Sessa et al. EMBO J 2021; 40 (7):e106018 BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair?.
Tognetti L et al. Photodermatol Photoimmunol Photomed 2021; Evaluation of 11-β hydroxysteroid dehydrogenase type 1 in cutaneous fibroblasts cultures of psoriatic lesional skin before and after narrow band-UVB phototherapy.
Application : WB
Chen T et al. Blood Adv 2021; (Epub) Multiple Myeloma Cells Depend on the DDI2/NRF1-mediated Proteasome Stress Response for Survival.
Application : WB
Vasarri M et al. Mar Drugs 2021; 19 (10) Posidonia oceanica (L.) Delile Dampens Cell Migration of Human Neuroblastoma Cells.
Application : WB
Reactivity : Human
Fan SZ et al. Aging Cell 2021;:e13510 Dietary citrate supplementation enhances longevity, metabolic health, and memory performance through promoting ketogenesis.
Application : WB
Reactivity : Drosophila
Lee TT et al. Aging Cell 2021; 20 (6):e13379 Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila.
Application : WB
Reactivity : Drosophila
Wang SH et al. J Exp Clin Cancer Res 2021; 40 (1):95 Insulin-like growth factor binding protein 3 promotes radiosensitivity of oral squamous cell carcinoma cells via positive feedback on NF-κB/IL-6/ROS signaling.
Application : WB
Reactivity : Human
Kiew LV et al. Biosens Bioelectron 2021; 183:113213 Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors.
Application : WB
Reactivity : Human
Shu CW et al. Environ Toxicol 2021; 36 (6):1173-1180 Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells.
Application : WB
Lai TH et al. J Reprod Immunol 2021; 145:103311 TGFβ1 induces in-vitro and ex-vivo angiogenesis through VEGF production in human ovarian follicular fluid-derived granulosa cells during in-vitro fertilization cycle.
Tsai YJ et al. J Clin Med 2021; 10 (3) Liver X Receptor Expression and Pentraxin 3 Production in Chronic Rhinosinusitis and Sinonasal Mucosal Fibroblast Cells.
Application : WB
Reactivity : Human
You X et al. Mol Metab 2021; 48:101203 Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling.
Application : WB
Wang HC et al. Int J Mol Sci 2021; 22 (5) Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer.
Application : WB
Reactivity : Human
Lam HYP et al. Parasitol Int 2021; 80:102231 Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain.
Application : WB
Reactivity : Mouse
Wenting Xu et al. Front Bioeng Biotechnol 2020; 8:606496 A New Method for Chromosomes Preparation by ATP-Competitive Inhibitor SP600125 via Enhancement of Endomitosis in Fish.
Chi-Hung R Or et al. Int J Mol Sci 2020; 21 (5) Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling.
Application : WB
Reactivity : Mouse
Lin YH et al. Biomedicines 2020; 8 (11) ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects.
Lam HYP et al. Biomolecules 2020; 10 (7) Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Ehl?n ? et al. Nat Commun 2020; 11 (1):1819 Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
Tsai LH et al. Sci Rep 2020; 10 (1):17817 Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer.
Application : WB
Reactivity : Human
Kometani T et al. Cancers (Basel) 2020; 12 (10) Increased Expression of NPM1 Suppresses p27Kip1 Function in Cancer Cells.
Application : WB
Wolfe AD et al. NAR Cancer 2020; 2 (4):zcaa027 The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity.
Application : WB
Reactivity : Human
Wang YY et al. PLoS Genet 2020; 16 (9):e1009020 Deficiency of the Tbc1d21 gene causes male infertility with morphological abnormalities of the sperm mitochondria and flagellum in mice.
Tsachaki M et al. Cell Mol Life Sci 2020; 77 (6):1153-1175 Impact of 17β-HSD12, the 3-ketoacyl-CoA reductase of long-chain fatty acid synthesis, on breast cancer cell proliferation and migration.
Chi H et al. Sci Rep 2020; 10 (1):13482 Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model.
Application : WB
Reactivity : Drosophila
Labus J et al. Prog Neurobiol 2020;:101900 Amelioration of Tau pathology and memory deficits by targeting 5-HT7 receptor.
Application : ICC/IF
Reactivity : Mouse
Patt M et al. Mol Cell Endocrinol 2020;:110873 Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211.
Application : WB
Reactivity : Human
Mohapatra S et al. Cell Death Differ 2020; (Epub) Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver.
Application : WB
Bogucka K et al. Elife 2020; 9 ERK3/MAPK6 controls IL-8 production and chemotaxis.
Application : WB
Reactivity : Human
Tseng TL et al. Toxicol Appl Pharmacol 2020; 400:115070 OroxylinA reverses lipopolysaccharide-induced adhesion molecule expression and endothelial barrier disruption in the rat aorta.
Application : ICC/IF
Reactivity : Rat
Chen PL et al. Nat Commun 2020; 11 (1):2592 Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.
Application : WB
Reactivity : Drosophila
Lai YW et al. Sci Rep 2020; 10 (1):5132 Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.
Application : WB
Reactivity : Drosophila
Yang H et al. Nat Commun 2020; 11 (1):632 Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
Application : WB
Reactivity : Human
Huang SW et al. J Cell Mol Med 2020; 24 (2):1822-1836 Lovastatin-mediated MCF-7 cancer cell death involves LKB1-AMPK-p38MAPK-p53-survivin signalling cascade.
Application : WB
Reactivity : Human
Chen TI et al. J Virol 2019; 93 (22) Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Nonhomologous End Joining.
Lieschke S et al. Cells 2019; 9 (1) CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age.
Application : WB
Reactivity : Mouse
Zhu Z et al. Life Sci Alliance 2019; 2 (6) The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.
Application : WB
Reactivity : Mouse
Zhang J et al. BMC Cancer 2019; 19 (1):921 Lentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer.
Application : WB
Reactivity : Human
Teng LL et al. PLoS Biol 2019; 17 (3):e2007097 Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.
Chang HW et al. Toxins (Basel) 2019; 11 (6) Xanthium strumarium Fruit Extract Inhibits ATG4B and Diminishes the Proliferation and Metastatic Characteristics of Colorectal Cancer Cells.
Chang CC et al. Nat Commun 2019; 10 (1):4307 Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α.
Application : ICC/IF
Reactivity : Human
Karki A et al. Oncol Rep 2019; MDM4 expression in fibrolamellar hepatocellular carcinoma.
Lien JC et al. Br J Pharmacol 2019; A novel 2-aminobenzimidazole-based compound Jzu 17 exhibits anti- angiogenesis effects via targeting VEGFR-2 signaling.
Chuang WT et al. J Agric Food Chem 2019; 67 (25):7136-7146 Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet.
Application : WB
Reactivity : Mouse
Liao KH et al. Brain Res 2019;:146320 Carbogen inhalation opens the blood-brain barrier in rats without causing long-term metabolic or neurological deficit.
Application : WB
Reactivity : Rat
Kikuma K et al. Nat Commun 2019; 10 (1):2998 Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.
Application : WB
Reactivity : Drosophila
Sonia L. Evagelou et al. bioRxiv 2019; (Epub) DEAD-box protein family member DDX28 is a negative regulator of HIF-2α and eIF4E2-directed hypoxic translation.
Application : WB
Reactivity : Human
Ma Z et al. Cell Biosci 2019; 9:34 Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis.
Application : WB
Reactivity : Human
Alard A et al. Front Genet 2019; 10:254 Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome.
Application : WB
Reactivity : Mouse
Chon-Kit Chou et al. Int J Mol Sci 2018; 19 (7) Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress.
Application : WB
Reactivity : Human
Tsachaki M et al. FASEB J 2018; 32 (5):2690-2705 Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance.
Galanos P et al. Genome Biol 2018; 19 (1):37 Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.
Shieh JM et al. J Cell Physiol 2018; (Epub) TGFβ mediates collagen production in human CRSsNP nasal mucosa-derived fibroblasts through Smad2/3-dependent pathway and CTGF induction and secretion.
Application : WB
Reactivity : Human
Walch L et al. Sci Rep 2018; 8 (1):17121 GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.
Application : WB
Reactivity : Human
Koto Kikuma et al. bioRxiv 2018; (Epub) The sleep gene insomniac ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling.
Application : WB
Reactivity : Drosophila
Zhang D et al. Med Sci Monit 2018; 24:6666-6672 mitochondrial dynamics in rat heart induced by 5-*.
Application : WB
Reactivity : Rat
Sun Y et al. Int J Oncol 2018; (Epub) identification of * sensitizers through high-throughput combinatorial screening.
Maya-Mendoza A et al. Nature 2018; 559 (7713):279-284 High speed of fork progression induces DNA replication stress and genomic instability.
Application : WB
Reactivity : Human
Irene Vorontsova et al. iOVS 2018; 59 (7) Aqp0a Regulates Suture Stability in the Zebrafish Lens.
Application : WB
Reactivity : Zebrafish
Yu-Lee LY et al. Cancer Res 2018; (Epub) Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway.
Application : WB
Reactivity : Human
Macdougall CE et al. Cell Metab 2018; 27 (3):588-601.e4 Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.
Application : WB
Reactivity : Mouse
Wilkie AR et al. J Virol 2018; (Epub) A role for myosin Va in human cytomegalovirus nuclear egress.
Application : WB
Reactivity : Human
Petra Gimpel et al. Curr Biol 2017; 27 (19):2999-3009.e9 Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
Application : WB
Reactivity : Mouse
Sivarapatna A et al. Cell Transplant 2017; 26 (8):1365-1379 Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.
Chang CW et al. Stem Cell Res 2017; 27:21-24 Generation of FHL2 homozygous knockout lines from human embryonic stem cells by CRISPR/Cas9-mediated ablation.
Application : WB
Reactivity : Human
Wu LH et al. J Cell Physiol 2017; (Epub) Laminar Shear Stress Promotes Mitochondrial Homeostasis in Endothelial Cells.
Application : WB
Reactivity : Human
Su CY et al. Eur J Pharm Biopharm 2017; Development and Characterization of Docetaxel-Loaded Lecithin-Stabilized Micellar Drug Delivery System (LsbMDDs) for Improving the Therapeutic Efficacy and Reducing Systemic Toxicity.
Huang SC et al. EMBO Mol Med 2017; (Epub) TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB.
Application : WB
Reactivity : Human
Lee YC et al. Int J Mol Sci 2017; 18 (9) Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2.
Application : WB
Reactivity : Human
Groussaud D et al. PLoS Pathog 2017; 13 (7):e1006518 Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription.
Application : WB
Reactivity : Human
Xiao X et al. Nucleic Acids Res 2017; (Epub) Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Application : WB
Reactivity : Human
Eshima H et al. Am J Physiol Regul Integr Comp Physiol 2017;:ajpregu.00032.2017 Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α.
Application : WB
Reactivity : Mouse
Eshima H et al. Physiol Rep 2017; 5 (7) Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle.
Application : WB
Reactivity : Mouse
Willkomm L et al. PLoS One 2017; 12 (5):e0176609 p38 MAPK activation and H3K4 trimethylation is decreased by lactate in vitro and high intensity resistance training in human skeletal muscle.
Application : WB
Yang CH et al. Arch Virol 2017; (Epub) Influenza A virus upregulates PRPF8 gene expression to increase virus production.
Huang WY et al. J Dermatol Sci 2017; (Epub) Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction.
Application : WB
Reactivity : Rat
Emily R Rowe et al. J Biol Chem 2016; 291 (13):6664-78 Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.
Application : WB
Reactivity : Mouse
Kuo-Wang Tsai et al. Sci Rep 2016; 6 (0):28176 Arm Selection Preference of MicroRNA-193a Varies in Breast Cancer.
Application : WB
Reactivity : Mouse
Gan Z et al. Cell Syst 2016; 3 (3):252-263.e8 Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration.
Application : WB
Reactivity : Human
Selagea L et al. FASEB J 2016; 30 (12):4098-4108 EGFR and C/EBP-β oncogenic signaling is bidirectional in human glioma and varies with the C/EBP-β isoform.
Application : WB
Reactivity : Human
Or CR et al. Int J Mol Sci 2016; 18 (1) Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells.
Application : WB
Reactivity : Human
Wang SH et al. Med Mycol 2016; (Epub) Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p38 pathways in human urinary epithelium.
Application : WB
Reactivity : Human
Funghi L et al. Mol Cell Endocrinol 2016; 437:163-170 Expression and regulation of 11β-hydroxysteroid dehydrogenase type 1 in first trimester human decidua cells: Implication in preeclampsia.
Application : WB
Reactivity : Human
Peng YJ et al. Sci Rep 2016; 6:32444 Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.
Application : WB
Reactivity : Human
Chang KH et al. CNS Neurosci Ther 2016; The Potential of Indole/Indolylquinoline Compounds in Tau Misfolding Reduction by Enhancement of HSPB1.
Application : WB
Reactivity : Human
Yamamoto K et al. Peptides 2016; 82:120-7 Contrasting effects of stanniocalcin-related polypeptides on macrophage foam cell formation and vascular smooth muscle cell migration.
Won SJ et al. J FUNCT FOODS 2016; 24:568-578 A novel natural tautomeric pair of garcinielliptone FC suppressed nuclear factor κB and induced apoptosis in human colorectal cancer cells.
Application : WB
Reactivity : Human
Weng C et al. J Biol Chem 2016; (Epub) miRNA-342 regulates CEACAM1-induced lumen formation in a 3D model of mammary gland morphogenesis.
Application : WB
Reactivity : Human
Kwon HJ et al. Nat Commun 2016; 7:11686 Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition.
Application : WB
Reactivity : Human
Choe KN et al. EMBO Rep 2016; (Epub) HUWE1 interacts with PCNA to alleviate replication stress.
Application : WB
Reactivity : Human
Lu JW et al. Cancer Lett 2016; (Epub) * is selectively cytotoxic in acute myeloid leukemia cells with flt3-internal tandem duplication (flt3-itd).
Application : WB
Reactivity : Human
Helen Wenshin Yu et al. J Cell Mol Med 2015; 19 (5):934-47 β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration.
Application : WB
Reactivity : Human
Wang C et al. PLoS One 2015; 10 (3):e0120913 combining * with abt-263 has a synergistic effect on * resistant prostate cancer cells.
Application : WB
Reactivity : Human
Bettens K et al. Mol Neurodegener 2015; 10:30 Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.
Application : WB
Reactivity : Human
Chuang YF et al. PLoS One 2015; 10 (8):e0137177 Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells.
Application : WB
Reactivity : Mouse
Chen WL et al. PLoS One 2015; 10 (9):e0137979 Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells.
Application : WB
Reactivity : Human
Tsai KN et al. J Virol 2015; 89 (22):11406-19 Doubly Spliced RNA of Hepatitis B Virus Suppresses Viral Transcription via TATA-Binding Protein and Induces Stress Granule Assembly.
Application : WB
Reactivity : Human
Huang YH et al. Sci Rep 2015; 5:15900 The effects of a novel aliphatic-chain hydroxamate derivative WMJ-S-001 in HCT116 colorectal cancer cell death.
Application : WB
Reactivity : Human
Khalil H et al. J Cell Sci 2015; 128 (18):3502-13 The caspase-3-p120-RasGAP module generates a NF-κB repressor in response to cellular stress.
Davide P et al. Cell Mol Gastroenterol Hepatol 2015; 1 (6):646-663 Lipid-Induced Hepatocyte-Derived Extracellular Vesicles Regulate Hepatic Stellate Cells via MicroRNA Targeting Peroxisome Proliferator-Activated Receptor γ.
Application : WB
Reactivity : Human
Naik NG et al. J Virol 2015; 89 (13):6746-60 Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication.
Application : WB
Reactivity : Human
Satow R et al. Proc Natl Acad Sci U S A 2014; 111 (37):13505-10 Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells.
Application : WB
Reactivity : Human
Chang LC et al. Br J Pharmacol 2014; 171 (17):4010-25 YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK.
Application : WB
Reactivity : Human
Pitts RJ et al. Proc Natl Acad Sci U S A 2014; 111 (7):2566-71 Odorant receptor-mediated sperm activation in disease vector mosquitoes.
Li KC et al. Mol Cancer 2014; 13:172 Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.
Application : WB
Reactivity : Human
Lin TY et al. PLoS One 2014; 9 (7):e101980 Hypoxia-Inducible Factor 2 Alpha Is Essential for Hepatic Outgrowth and Functions via the Regulation of leg1 Transcription in the Zebrafish Embryo.
Application : WB
Reactivity : Zebrafish
Emhemmed F et al. Biochem Pharmacol 2014; Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.
Application : WB
Reactivity : Human
Chu TH et al. J Virol 2014; 88 (5):2530-43 Nucleic Acid chaperone activity associated with the arginine-rich domain of human hepatitis B virus core protein.
Application : WB
Reactivity : Human
Katrin Ruisu et al. PLoS One 2013; 8 (8):e74031 Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death.
Application : WB
Reactivity : Human
Yi-Cheng Chang et al. EMBO Mol Med 2013; 5 (8):1165-79 Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Application : WB
Reactivity : Drosophila
Carla Angulo-Rojo et al. ASN Neuro 2013; 5 (5):e00130 Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA.
Application : WB
Reactivity : Human
Bailey CC et al. J Biol Chem 2013; 288 (45):32184-93 *-induced transmembrane protein 3 is a type ii transmembrane protein.
Application : ICC/IF
Eshima H et al. Am J Physiol Regul Integr Comp Physiol 2013; 305 (6):R610-8 In vivo imaging of intracellular Ca2+ after muscle contractions and direct Ca2+ injection in rat skeletal muscle in diabetes.
Application : WB
Reactivity : Rat
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