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beta Catenin antibody [15B8] (Cy3)

Cat No. GTX11348

Host Mouse
Clonality Monoclonal
Clone Name 15B8
Isotype IgG1
Application WB, ICC/IF
Reactivity Human, Bovine, Dog, Chicken
Package
100 μl ($329)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF 1:100
Not tested in other applications.

Positive Control

MDBK

Specificity/Sensitivity

Recognizes specifically mammalian and avian β-catenin. Does not cross-react with plakoglobin (γ-catenin).
PROPERTIES

Form

Liquid

Buffer

0.01M PBS pH7.4, 1% bovine serum albumin, 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

~1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Chicken

Immunogen

recombinant chicken β-catenin.

Purification

Purified immunoglobulin

Conjugation

Cyanine3 (Cy3)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Catenin Beta 1,Chbcat,Ctnnb1

Background

The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kD) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Research Area

REFERENCE
There are currently no references for beta Catenin antibody [15B8] (Cy3) (GTX11348). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for beta Catenin antibody [15B8] (Cy3) (GTX11348). Be the first to share your experience with this product.
Package List Price ($)
$ 329