Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
synthetic peptide corresponding to the C-terminal sequence of β-tubulin isotype IV, conjugated to BSA.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
tubulin beta 4A class IVa , DYT4 , TUBB4 , beta-5
The major building block of microtubules is tubulin, an intracellular cylindrical filamentous structure that is present in almost all eukaryotic cells. Except in the simplest eukaryotes, tubulin exists in all cells as a 100 kD protein, a heterodimer of two similar but not identical polypeptides, designated alpha and beta, that assembles into microtubules. Both alpha and beta tubulins consist of various isotypes. For beta tubulin, six evolutionarily conserved isotypes were identified (designated beta I-beta VI). Beta IV exists as two subtypes in mammals, differing from each other at 10 positions. beta IVa is brain specific, whereas beta IVb is ubiquitous, and both appear to be constitutive. The detection, localization and characterization of proteins involved in microtubule function is fundamental to the understanding of mitosis, meiosis, organellar and flagellar movement, intracellular transport, and cytoskeletal functions.