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CD3 antibody [F7.2.38]

Anti-CD3 antibody [F7.2.38] used in IHC (Paraffin sections) (IHC-P). GTX17143

Cat. No. GTX17143

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 F7.2.38

Isotype

 IgG1

Application

 ICC/IF, IHC-P

Reactivity

 Human
Package
500 μl ($749)
See all CD3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P 1:10‐1:25

Note :

IHC-P
Recommendations for antigen retrieval : EDTA buffer pH 8.0 at room temperature for 30 mins.
Not tested in other applications.

Calculated MW

19 kDa. ( Note )

Product Note

This antibody labels CD3ε and is a useful tool for the identification of T cells and related neoplasms.

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Purified CD3εγδ/CD3ω

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_422603

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD3d molecule , CD3-DELTA , IMD19 , T3D

Cellular Localization

Cell membrane; Single-pass type I membrane protein

Background

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Database

Research Area

DATA IMAGES

Anti-CD3 antibody [F7.2.38] used in IHC (Paraffin sections) (IHC-P). GTX17143

GTX17143 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX17143 CD3 antibody [F7.2.38].

REFERENCE

Application Reference

Kobayashi A et al. Mucosal Immunol 2008; 1 (5) : 412-20 Evolving immunosuppressive microenvironment during human cervical carcinogenesis.
Application : ICC/IF
Reactivity : Human
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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 749