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Somatostatin antibody [SOM-018]

Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935
Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935
Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935
Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935

Cat. No. GTX71935

Reference 45

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 SOM-018

Isotype

 IgG1

Application

 ICC/IF, IHC-P, IHC-Fr, IHC

Reactivity

 Human, Mouse, Rat
Package
500 μl ($399)
See all Somatostatin products

APPLICATION

Application Note

Recommended Starting Dilutions:
For ICC/IF: Use at a dilution of 1:25-1:100
For IHC-Fr: Use at a dilution of 1:25-1:100
For IHC-P: Use at a dilution of 1:25-1:100
Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

13 kDa. ( Note )

Positive Control

Pancreas

Product Note

The epitope recognised by this antibody lies within the Somatostatin-14.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.2% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.14 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Somatostatin conjugated to a protein carrier

Purification

Protein A affinity purified

Conjugation

Unconjugated

RRID

AB_383280

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

somatostatin , SMST

Cellular Localization

Secreted

Background

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935

GTX71935 IHC Image

The data was published in the journal Hippocampus in 2017. PMID: 27997999

Anti-Somatostatin antibody [SOM-018] used in Immunohistochemistry (IHC). GTX71935

GTX71935 IHC Image

The data was published in the journal Hippocampus in 2017. PMID: 27997999

Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935

GTX71935 IHC-Fr Image

The data was published in the journal J Neurosci in 2019.PMID: 30926750

Anti-Somatostatin antibody [SOM-018] used in IHC (Frozen sections) (IHC-Fr). GTX71935

GTX71935 IHC-Fr Image

The data was published in the journal J Neurosci in 2019.PMID: 30926750

REFERENCE

Application Reference

Kondabolu K et al. eNeuro 2023; 10 (7) A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.
Galer EL et al. J Neurosci 2023; 43 (3) : 419-432 Cervical Epidural Electrical Stimulation Increases Respiratory Activity through Somatostatin-Expressing Neurons in the Dorsal Cervical Spinal Cord in Rats.
Application : IHC-Fr
Reactivity : Rat
Lukacs IP et al. Cereb Cortex 2023; 33 (5) : 2101-2142 Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex.
Application : ICC/IF
Reactivity : Human
De-Fong Huang et al. 2022; 119 (33) Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons.
Application : IHC-Fr
Reactivity : Mouse
Esi Domi et al. Sci Adv 2021; 7 (34) A neural substrate of compulsive alcohol use.
Application : IHC
Reactivity : Rat
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REVIEW

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Application Reference
Kondabolu K et al. eNeuro 2023; 10 (7) A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.
Galer EL et al. J Neurosci 2023; 43 (3):419-432 Cervical Epidural Electrical Stimulation Increases Respiratory Activity through Somatostatin-Expressing Neurons in the Dorsal Cervical Spinal Cord in Rats.
Application : IHC-Fr
Reactivity : Rat
Lukacs IP et al. Cereb Cortex 2023; 33 (5):2101-2142 Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex.
Application : ICC/IF
Reactivity : Human
De-Fong Huang et al. 2022; 119 (33) Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons.
Application : IHC-Fr
Reactivity : Mouse
Esi Domi et al. Sci Adv 2021; 7 (34) A neural substrate of compulsive alcohol use.
Application : IHC
Reactivity : Rat
Sato K et al. J Virol 2021; 95 (21):e0129621 TMPRSS2 Activates Hemagglutinin-Esterase Glycoprotein of Influenza C Virus.
Application : IHC-Fr
Reactivity : Rat
Liu J et al. Front Neuroanat 2021; 15:662724 Molecular Characterization of Superficial Layers of the Presubiculum During Development.
Yamamoto T et al. Acta Histochem Cytochem 2020; 53 (5):121-129 The Chemokine CXCL14-like Immunoreactivity Co-exists with Somatostatin, but not NPY in the Rat Dorsal Horn and Has Intimate Association with GABAergic Neurons in the Lateral Spinal Nucleus.
Sato M et al. Cell Rep 2020; 32 (1):107864 Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.
Zhu JW et al. Cereb Cortex 2019; (Epub) Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling.
Application : IHC-P
Reactivity : Mouse
Salib M et al. J Neurosci 2019; 39 (23):4527-4549 GABAergic Medial Septal Neurons with Low-Rhythmic Firing Innervating the Dentate Gyrus and Hippocampal Area CA3.
Nelson TS et al. Sci Rep 2019; 9 (1):7248 Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn.
Application : IHC-Fr
Reactivity : Rat
Han P et al. Am J Transl Res 2019; 11 (3):1389-1402 Artemether ameliorates type 2 diabetic kidney disease by increasing mitochondrial pyruvate carrier content in db/db mice.
Application : IHC-P
Reactivity : Human
Sato M et al. bioRxiv 2018; (Epub) Dynamic embedding of salience coding in hippocampal spatial maps.
Application : IHC
Joshi A et al. Neuron 2017; 96 (6):1342-1357.e5 Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area.
Reactivity : Mouse
Okuyama T et al. Sci Rep 2017; 7 (1):2364 Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.
Application : IHC-P
Reactivity : Mouse
Yuan M et al. Elife 2017; 6 Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition.
Application : IHC
Liang T et al. J Biol Chem 2016; (Epub) new roles of syntaxin-1a in * granule exocytosis and replenishment.
Application : ICC/IF
Reactivity : Mouse
Katona L et al. Hippocampus 2016; (Epub) Behavior-dependent activity patterns of GABAergic long-range projecting neurons in the rat hippocampus.
Damborsky JC et al. Brain Struct Funct 2016; Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin.
Application : IHC-Fr
Reactivity : Mouse
Dolai S et al. Diabetes 2016; (Epub) synaptotagmin-7 functions to replenish * granules for exocytosis in human islet β-cell.
Bienvenu TC et al. J Neurosci 2015; 35 (5):2044-57 Large intercalated neurons of amygdala relay noxious sensory information.
Blodgett DM et al. Diabetes 2015; 64 (9):3172-81 Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets.
Unal G et al. J Neurosci 2015; 35 (48):15812-26 Synaptic Targets of Medial Septal Projections in the Hippocampus and Extrahippocampal Cortices of the Mouse.
Orban-Kis K et al. Rom J Morphol Embryol 2015; 56 (1):155-61 The loss of Ivy cells and the hippocampal input modulatory O-LM cells contribute to the emergence of hyperexcitability in the hippocampus.
Application : ICC/IF
Reactivity : Rat
Krasowska E et al. PLoS One 2014; 9 (9):e108364 Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy.
Maguire EP et al. J Neurosci 2014; 34 (3):823-38 Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants.
F. Aragon et al. Biochimica et Biophysica Acta (BBA) - General Subjects 2014; 1850 (2):343-351
Application : ICC/IF
Reactivity : Mouse
Milenkovic I et al. Neuroscience 2013; 254:80-96 The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits alpha1, beta2, and delta along their extrasynaptic cell membrane.
Application : ICC/IF
Reactivity : Mouse
Huang YC et al. Diabetes 2013; 62 (2):519-30
Application : ICC/IF
Reactivity : Mouse
Somogyi J et al. Front Neural Circuits 2012; 6:35 Molecular analysis of ivy cells of the hippocampal CA1 stratum radiatum using spectral identification of immunofluorophores.
Chen CY et al. Hum Mol Genet 2012; 21 (19):4270-85 Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation.
Application : IHC
Reactivity : Mouse
Hong ME et al. Korean J Physiol Pharmacol 2011; 15 (3):137-42 Influence of exposure to extremely low frequency magnetic field on neuroendocrine cells and hormones in stomach of rats.
Corteen NL et al. Eur J Neurosci 2011; 34 (2):250-62 Localization of GABA-A receptor alpha subunits on neurochemically distinct cell types in the rat locus coeruleus.
Application : IHC
Reactivity : Rat
Huang YC et al. J Physiol 2011; 589 (Pt 2):395-408 Unperturbed islet α-cell function examined in mouse pancreas tissue slices.
Application : IHC
Reactivity : Mouse
Lasztoczi B et al. J Neurosci 2011; 31 (49):18073-93 Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
Application : ICC/IF
Reactivity : Rat
Romero-Zerbo SY et al. J Endocrinol 2011; 211 (2):177-85 A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
Takahashi H et al. Appl Environ Microbiol 2011; 77 (19):6964-71 Role of indigenous lactobacilli in gastrin-mediated acid production in the mouse stomach.
Application : IHC
Reactivity : Human
Matsuo T et al. Regul Pept 2010; 163 (43103):15919 Localization of neuroendocrine regulatory peptide-1 and-2 in human tissues.
Application : IHC
Reactivity : Human
Fujita Y et al. Gastroenterology 2010; 138 (5):1966-75 glucose-dependent *otropic polypeptide is expressed in pancreatic islet alpha-cells and promotes * secretion.
Application : IHC
Best L et al. Cell Physiol Biochem 2009; 23 (43196):255-64 Contrasting effects of glycerol and urea transport on rat pancreatic beta-cell function.
Application : IHC-P
Reactivity : Rat
Liu F et al. J Neurosci 2009; 29 (16):5075-87 Brain injury does not alter the intrinsic differentiation potential of adult neuroblasts.
Application : ICC/IF
Reactivity : Human
Panguluri S et al. Brain Res 2009; 1298:57-69 Comparison of somatostatin and corticotrophin-releasing hormone immunoreactivity in forebrain neurons projecting to taste-responsive and non-responsive regions of the parabrachial nucleus in rat.
Application : IHC
Reactivity : Rat
Wolf-Goldberg T et al. Mol Pharmacol 2006; 70 (3):818-28 Target soluble N-ethylmaleimide-sensitive factor attachment protein receptors (t-SNAREs) differently regulate activation and inactivation gating of Kv2.2 and Kv2.1: Implications on pancreatic islet cell Kv channels.
Application : IHC
Reactivity : Mouse
Leung YM et al. Endocrinology 2006; 147 (5):2155-62 * regulates islet alpha-cell function by reducing katp channel sensitivity to adenosine 5'-triphosphate inhibition.
Application : ICC/IF
Reactivity : Human
SDS
Sodium Azide.pdf
Package List Price ($)
$ 399