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4-1BBL / CD137L antibody

Anti-4-1BBL / CD137L antibody used in IHC (Paraffin sections) (IHC-P). GTX31161

Cat No. GTX31161

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human
Package
100 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

27 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, pH 7.2

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant Human 4-1BB Ligand

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Tnf Superfamily Member 9 , 4-1Bb-L , Cd137L , Tnlg5A , Tnfsf9

Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES

Anti-4-1BBL / CD137L antibody used in IHC (Paraffin sections) (IHC-P). GTX31161

GTX31161 IHC-P Image

IHC-P analysis of human colon/rectum adenocarcinoma using 4-1BBL / CD137L antibody at a concentration of 0.25 mg/ml. An HRP-labeled polymer detection system was used with a DAB chromogen. Proteinase K antigen retrieval is recommended.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 319