GeneTex
United States (US)

4-1BBL / CD137L antibody

GTX31161_IHC-P_18121410_479.jpg

Cat No. GTX31161

Host Rabbit
Clonality Polyclonal
Application WB, IHC-P, ELISA
Reactivity Human
APPLICATION

Calculated MW

27 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS, pH 7.2

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant Human 4-1BB Ligand

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

tumor necrosis factor (ligand) superfamily, member 9 Antibody , 4-1BB-L Antibody , TNFSF9 Antibody , CD137L Antibody

Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

Database

Research Area

DATA IMAGES
GTX31161_IHC-P_18121410_479.jpg

GTX31161 IHC-P Image

IHC-P analysis of human colon/rectum adenocarcinoma using 4-1BBL / CD137L antibody at a concentration of 0.25 mg/ml. An HRP-labeled polymer detection system was used with a DAB chromogen. Proteinase K antigen retrieval is recommended.

Package List Price ($)
$ 319