APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Daudi , human fetal heart , human fetal liver , human fetal lung , human fetal muscle
PROPERTIES
Form
Liquid
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide corresponding to a N-terminal region of Human 5-HT2C receptor
Purification
Protein A purified
Conjugation
Unconjugated
RRID
AB_424648
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
5-hydroxytryptamine receptor 2C , 5-HT1C , 5-HT2C , 5-HTR2C , 5HTR2C , HTR1C
Cellular Localization
Cell membrane
Background
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
Database
Research Area
DATA IMAGES
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GTX77700 WB Image
WB analysis of Daudi and Raji cells using GTX77700 5-HT2C receptor antibody at 5.0μg/ml.
Lane A: Daudi cells
Lane B: Raji cells
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GTX77700 WB Image
WB analysis of human fetal liver tissue using GTX77700 5-HT2C receptor antibody at 1μg/ml.
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GTX77700 WB Image
WB analysis of human fetal muscle tissue using GTX77700 5-HT2C receptor antibody at 1μg/ml.
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GTX77700 WB Image
WB analysis of human fetal lung tissue using GTX77700 5-HT2C receptor antibody at 1μg/ml.
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GTX77700 WB Image
WB analysis of human fetal heart tissue using GTX77700 5-HT2C receptor antibody at 1μg/ml.
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REFERENCE
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REVIEW
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