5-Lipoxygenase (phospho Ser523) antibody

Cat. No. GTX82744

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB
Reactivity	Human, Rat
Package	100 μl ($499)

See all 5-Lipoxygenase products

Datasheet
Document

View product citations for antibody GTX82744 on CiteAb

APPLICATION

Application Note

Optimal working dilutions should be determined experimentally by the end user.

Calculated MW

78 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM HEPES, 150mM NaCl, 0.01% BSA, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser523 conjugated to KLH

Purification

Affinity Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

arachidonate 5-lipoxygenase , 5-LO , 5-LOX , 5LPG , LOG5

Cellular Localization

Cytoplasm

Background

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Database

Gene ID: 240 ALOX5
UniProt: P09917 ALOX5

Research Area

DATA IMAGES

GTX82744 WB Image

Western blot of rat hippocampal lysate showing phospho-specific immunolabeling of the ~80k doublet of 5-LO phosphorylated at Ser 523 using 5-Lipoxygenase (phospho Ser523) antibody (GTX82744).

REFERENCE

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SDS
Glycerol.pdf

Package

List Price ($)

100 μl

$ 499

Qty