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53BP1 antibody

Anti-53BP1 antibody used in Western Blot (WB). GTX70316

Cat No. GTX70316

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB

Reactivity

Human
Package
50 μl ($319)

APPLICATION

Application Note

For WB: Use at a dilution of 1:500. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

214 kDa. ( Note )

Positive Control

HeLa whole cell lysate

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.2, containing no preservatives

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to the amino-terminus of h53BP1, conjugated to a carrier protein.

Purification

Affinity purified with antigen
From polyclonal serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Tumor Protein P53 Binding Protein 1 , 53Bp1 , Tdrd30 , P202 , P53Bp1 , Tp53Bp1

Background

P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.

Database

Research Area

DATA IMAGES

Anti-53BP1 antibody used in Western Blot (WB). GTX70316

GTX70316 WB Image

REFERENCE

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REVIEW

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