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8-Hydroxyguanosine antibody [15A3]

Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980
Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980
Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980
Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980

Cat. No. GTX41980

Reference 18

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 15A3

Isotype

 IgG2b

Application

 ICC/IF, IHC-P, IHC-Fr, FACS, IP, Dot, ELISA, Activation, IHC

Reactivity

 Species independent
Package
100 μg ($399)
See all 8-Hydroxyguanosine products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Dot Assay dependent
ELISA Assay dependent
Activation Assay dependent
IHC Assay dependent
Not tested in other applications.

Product Note

Recognizes markers of oxidative damage to DNA (8-hydroxy-2’-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine).

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

8-hydroxy-guanosine-BSA and –casein conjugates

Purification

Protein G Purified

Conjugation

Unconjugated

RRID

AB_10732443

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

8OHdG , 8 hydroxyguanine , 80G , 8-OH-dG , 8OHG , 8 Hydroxyguanosine , 8 OHdG , 8hydroxyguanine , 8 OH dG

Research Area

DATA IMAGES

Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980

GTX41980 IHC-P Image

IHC-P analysis of mouse back skin tissue using GTX41980 8-Hydroxyguanosine antibody [15A3] antibody.
Dilution : 1:100

Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980

GTX41980 IHC-P Image

IHC-P analysis of ischemic fresh rat brain tissue using GTX41980 8-Hydroxyguanosine antibody [15A3] antibody.
Red : Primary antibody
Blue : DAPI
Localization: Cerebral Cortex
Dilution : 1:1000 for 16 hours at RT

Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980

GTX41980 IHC-P Image

IHC-P analysis of mouse retinal injury tissue using GTX41980 8-Hydroxyguanosine antibody [15A3] antibody.
Red : Primary ntibody
Dilution : 1:1000

Anti-8-Hydroxyguanosine antibody [15A3] used in IHC (Paraffin sections) (IHC-P). GTX41980

GTX41980 IHC-P Image

IHC-P analysis of inflamed mouse colon tissue using GTX41980 8-Hydroxyguanosine antibody [15A3] antibody. Mayer Hematoxylin (purple/blue) for nuclear staining.
Dilution : 1:1000000 for 12 hours at 4ºC

REFERENCE

Application Reference

S Venugopal et al. Pharm Sci 2024; 30 (2) : x-x Biogenic Zinc Oxide Nanoparticles Attenuate Acute Lymphoblastic Leukemia Cell Proliferation through Oxidative Stress and DNA Damage
Application : ICC/IF
P?rez-Figueroa DC et al. Iran J Basic Med Sci 2023; 26 (7) : 760-767 Evaluation of renal damage in a bleomycin-induced murine model of systemic sclerosis.
Han YC et al. Sci Rep 2023; 13 (1) : 11088 VDR alleviates endothelial cell injury in arteriovenous fistula through inhibition of P66Shc-mediated mitochondrial ROS.
Jeon J et al. Adv Sci (Weinh) 2023; 10 (14) : e2205161 Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.
Su W et al. JHEP Rep 2023; 5 (5) : 100695 TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.
Application : Activation
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REVIEW

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Application Reference
S Venugopal et al. Pharm Sci 2024; 30 (2):x-x Biogenic Zinc Oxide Nanoparticles Attenuate Acute Lymphoblastic Leukemia Cell Proliferation through Oxidative Stress and DNA Damage
Application : ICC/IF
P?rez-Figueroa DC et al. Iran J Basic Med Sci 2023; 26 (7):760-767 Evaluation of renal damage in a bleomycin-induced murine model of systemic sclerosis.
Han YC et al. Sci Rep 2023; 13 (1):11088 VDR alleviates endothelial cell injury in arteriovenous fistula through inhibition of P66Shc-mediated mitochondrial ROS.
Jeon J et al. Adv Sci (Weinh) 2023; 10 (14):e2205161 Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway.
Su W et al. JHEP Rep 2023; 5 (5):100695 TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.
Application : Activation
Yoon CH et al. Int J Mol Sci 2022; 23 (16) The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice.
Application : IHC
Yoon CH et al. Int J Mol Sci 2020; 21 (11) Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
Yang SK et al. Biomed Pharmacother 2020; 130:110521
Callejas BE et al. Int J Cancer 2019; (Epub) Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-庥B and STAT3 regulation.
Application : IHC-P
Nithyananthan S et al. J Cell Physiol 2019; (Epub) Arsenic trioxide, a cancer chemo drug hampers fibrotic liver regeneration by interrupting oxidative stress rekindling and stellate cell rejuvenation.
Teng RJ et al. Am J Physiol Lung Cell Mol Physiol 2017; 312 (5):L586-L598 Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury.
Alshammari GM et al. Mol Biol Rep 2017; 44 (6):463-474 Nimbolide attenuate the lipid accumulation, oxidative stress and antioxidant in primary hepatocytes.
Kong X et al. Oncotarget 2017; 8:104492-104507 Neuroprotective effects of allicin on ischemia-reperfusion brain injury.
Application : IHC-Fr
Subastri A et al. J Cell Physiol 2017; Troxerutin with copper generates oxidative stress in cancer cells: its possible chemotherapeutic mechanism against hepatocellular carcinoma.
Application : ICC/IF, IHC-P
Wu CL et al. Free Radic Biol Med 2017; 112:43457 Linking arsenite- and cadmium-generated oxidative stress to microsatellite instability in vitro and in vivo.
Application : ICC/IF
Diaz-Juarez J et al. Am J Physiol Cell Physiol 2016; 311 (6):C1005-C1013 Expression of the mitochondrial calcium uniporter in cardiac myocytes improves impaired mitochondrial calcium handling and metabolism in simulated hyperglycemia.
Application : ICC/IF
Hou XB et al. Biomed Pharmacother 2016; (Epub) combination of 2-deoxy d-glucose and * for synergistic inhibition of non-small cell lung cancer: a reactive oxygen species and p-p38 mediated mechanism.
Application : ICC/IF
Cividini F et al. J Biol Chem 2016; (Epub) O-GlcNAcylation of Ogg1 Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts.
Application : IHC-Fr
SDS
PBS.pdf
Glycerol.pdf
Package List Price ($)
$ 399