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AATF antibody

Anti-AATF antibody used in IHC (Paraffin sections) (IHC-P). GTX85086
Anti-AATF antibody used in IHC (Paraffin sections) (IHC-P). GTX85086
Anti-AATF antibody used in Western Blot (WB). GTX85086

Cat No. GTX85086

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human, Mouse
Package
100 μg ($389)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

Positive Control

Human Small Intestine Tissue Lysate(GTX27923) , Human Small Intestine Tissue Slide

PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

AATF antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human AATF.The immunogen is located within the last 50 amino acids of AATF.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

apoptosis antagonizing transcription factor , BFR2 , CHE-1 , CHE1 , DED

Cellular Localization

Nucleolus

Background

AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer’s disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.

Database

Research Area

DATA IMAGES

Anti-AATF antibody used in IHC (Paraffin sections) (IHC-P). GTX85086

GTX85086 IHC-P Image

IHC-P analysis of human small intestine tissue using GTX85086 AATF antibody.
Working concentration : 10 μg/ml

Anti-AATF antibody used in IHC (Paraffin sections) (IHC-P). GTX85086

GTX85086 IHC-P Image

IHC-P analysis of human small intestine tissue using GTX85086 AATF antibody.
Working concentration : 20 μg/ml

Anti-AATF antibody used in Western Blot (WB). GTX85086

GTX85086 WB Image

WB analysis of human small intestine tissue lysate using GTX85086 AATF antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 389