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ABAT antibody

Anti-ABAT antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32420
Anti-ABAT antibody used in IHC (Paraffin sections) (IHC-P). GTX32420
Anti-ABAT antibody used in Western Blot (WB). GTX32420
Anti-ABAT antibody used in IHC (Paraffin sections) (IHC-P). GTX32420
Anti-ABAT antibody used in IHC (Paraffin sections) (IHC-P). GTX32420

Cat No. GTX32420

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-P
Reactivity Human, Mouse, Rat
Package
100 μl ($329)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
ICC/IF 1:50 - 1:200
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

56 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 29-300 of human ABAT (NP_001120920.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

4-Aminobutyrate Aminotransferase,Gaba-At,Gabat,Npd009,Abat

Background

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-ABAT antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX32420

GTX32420 ICC/IF Image

ICC/IF analysis of A549 cell using GTX32420 ABAT antibody.
Blue : DAPI

Anti-ABAT antibody used in IHC (Paraffin sections) (IHC-P). GTX32420

GTX32420 IHC-P Image

IHC-P analysis of human liver injury tissue using GTX32420 ABAT antibody.
Dilution : 1:100

Anti-ABAT antibody used in Western Blot (WB). GTX32420

GTX32420 WB Image

WB analysis of various samples using GTX32420 ABAT antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-ABAT antibody used in IHC (Paraffin sections) (IHC-P). GTX32420

GTX32420 IHC-P Image

IHC-P analysis of human gastric cancer tissue using GTX32420 ABAT antibody.
Dilution : 1:100

Anti-ABAT antibody used in IHC (Paraffin sections) (IHC-P). GTX32420

GTX32420 IHC-P Image

IHC-P analysis of rat kidney tissue using GTX32420 ABAT antibody.
Dilution : 1:100

REFERENCE
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REVIEW
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Package List Price ($)
$ 329