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ABCA4 (Rim Protein) antibody [3F4]

Anti-ABCA4 (Rim Protein) antibody [3F4] used in Immunohistochemistry (IHC). GTX82741

Cat. No. GTX82741

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 3F4

Isotype

 IgG

Application

 WB, IHC

Reactivity

 Human, Mouse, Bovine, Xenopus laevis
Package
100 μl ($499)
See all ABCA4 products

APPLICATION

Application Note

Optimal working dilutions should be determined experimentally by the end user.

Calculated MW

260 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM HEPES, 150mM NaCl, 0.01% BSA, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Bovine

Immunogen

Partially purified bovine 220-kDa disc rim protein

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATP-binding cassette, sub-family A (ABC1), member 4 , AW050280 , Abc10 , Abcr , D430003I15Rik , RmP

Cellular Localization

Membrane

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein was the first of the ABC transporters to be observed in photoreceptors and may play a role in the photoresponse. Mutations in the human gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-ABCA4 (Rim Protein) antibody [3F4] used in Immunohistochemistry (IHC). GTX82741

GTX82741 IHC Image

Immunohistochemical staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein using ABCA4 (Rim Protein) antibody [3F4] (GTX82741).

REFERENCE

Application Reference

?cie?y?ska A et al. Int J Mol Sci 2023; 24 (9) Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes.

Clone Reference

Illing M et al. J Biol Chem 1997; 272 (15):10303-10 The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily.
Application : WB
Reactivity : Bovine
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SDS
Glycerol.pdf
Package List Price ($)
$ 499