GeneTex
United States (US)

ABCG8 antibody

KO/KD
GTX30466_1407_WB_18121410_785.jpg

Cat No. GTX30466

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500
Not tested in other applications.

Calculated MW

76 kDa. ( Note )

Specificity/Sensitivity

This product does not react with Mouse.
PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide from the N-terminal region of human ABCG8 protein. [UniProt# Q9H221]

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Atp Binding Cassette Subfamily G Member 8,Gbd4,Stsl,Abcg8

Cellular Localization

Membrane

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq]

Database

DATA IMAGES
GTX30466_1407_WB_18121410_785.jpg

GTX30466 WB Image

KO/KD

WB analysis of mouse liver microsomes from abcg5/abcg8 knockout mice, wildtype human abcg5/abcg8, and transgenic human abcg5/abcg8 using GTX30466 ABCG8 antibody.

REFERENCE
Package List Price ($)
$ 329