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ABCG8 antibody

KO/KD
Anti-ABCG8 antibody used in Western Blot (WB). GTX30466
Anti-ABCG8 antibody used in Western Blot (WB). GTX30466

Cat. No. GTX30466

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μl ($399)
See all ABCG8 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
Not tested in other applications.

Calculated MW

76 kDa. ( Note )

Product Note

We do not recommend use of this product for Mouse samples.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide from the N-terminal region of human ABCG8 protein. [UniProt# Q9H221]

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_385628

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATP binding cassette subfamily G member 8 , GBD4 , STSL

Cellular Localization

Cell membrane,Apical cell membrane

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-ABCG8 antibody used in Western Blot (WB). GTX30466

GTX30466 WB Image

KO/KD

WB analysis of mouse liver microsomes from abcg5/abcg8 knockout mice, wildtype human abcg5/abcg8, and transgenic human abcg5/abcg8 using GTX30466 ABCG8 antibody.

Anti-ABCG8 antibody used in Western Blot (WB). GTX30466

GTX30466 WB Image

The data was published in the journal PLoS One in 2016.PMID: 27023132

REFERENCE

Application Reference

Nakano T et al. PLoS One 2016; 11 (3) : e0152207 Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine.
Application : WB
Reactivity : Human
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399