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ACE2 antibody [AC384]

Anti-ACE2 antibody [AC384] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX03176

Cat No. GTX03176

Host

Mouse

Clonality

Monoclonal

Clone Name

AC384

Isotype

IgG1

Application

WB, ELISA, Neutralizing/Inhibition

Reactivity

Human
Package
100 μg ($369)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:2000-1:10000
ELISA 1:2000-1:10000
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
Blocks the binding of human ACE2 to the Spike protein of SARS-Cov-2. Does not affect the enzymatic activity of human ACE2.

Not tested in other applications.

Calculated MW

92 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human ACE2.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

angiotensin I converting enzyme 2 , ACEH

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-ACE2 antibody [AC384] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX03176

GTX03176 Neutralizing/Inhibition Image

Binding of ACE2 to the SARS-CoV-2 Spike S1 (RBD) protein is inhibited by the antibody GTX03176 ACE2 antibody [AC384]. GTX03176 ACE2 antibody [AC384] or an unrelated mAb Control are added (starting at 40μg/ml with a two-fold serial dilution) together with 500ng/μl of ACE2 fused at the C-terminus to a DDDDK-tag.
Coating : SARS-CoV-2 Spike S1 (RBD) protein coated on an ELISA plate at 1μg/ml
Detection : DDDDK antibody

REFERENCE

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REVIEW

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