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ACE2 antibody

Anti-ACE2 antibody used in Western Blot (WB). GTX15349
Anti-ACE2 antibody used in IHC (Paraffin sections) (IHC-P). GTX15349
Anti-ACE2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15349

Cat No. GTX15349

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P, ELISA

Reactivity

Human
Package
100 μg ($359)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
ICC/IF Assay dependent
IHC-P 2 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

92 kDa. ( Note )

Positive Control

Human Kidney Tissue Lysate(GTX29995)

Specificity/Sensitivity

Anti-ACE2 has no cross response to ACE1.

PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.The immunogen is located within amino acids 150 - 200 of ACE2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

angiotensin I converting enzyme 2 , ACEH

Cellular Localization

Cytoplasm

Background

Angiotensin converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE1 inhibitors such as catopril and lisinopril do not block ACE2 activity. ACE2 is restricted to the testis, heart, kidney and colon. The full length sequence for ACE2 encodes an 805 amino acid protein with predicted mass of 92.46 kDa and a pI of 5.22. No cross reactivity to ACE1.

Database

Research Area

DATA IMAGES

Anti-ACE2 antibody used in Western Blot (WB). GTX15349

GTX15349 WB Image

WB analysis of human kidney lysate using GTX15349 ACE2 antibody.
Working concentration : 2 μg/ml

Anti-ACE2 antibody used in IHC (Paraffin sections) (IHC-P). GTX15349

GTX15349 IHC-P Image

IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody.
Working concentration : 2 μg/ml

Anti-ACE2 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX15349

GTX15349 ICC/IF Image

IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody.
Working concentration : 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf