GeneTex
United States (US)

ACMSD antibody [N2C3]

GTX106739_40135_WB_M_brain_19011506_800.jpg
GTX106739_40135_IHC_19011506_596.jpg
GTX106739_WB_19011506_319.jpg

Cat No. GTX106739

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

38 kDa. ( Note )

Positive Control

293T , A431 , H1299 , HeLa , Molt-4 , Raji , mouse brain

Predict Reactivity

Rat, Zebrafish, Bovine(>80% identity)
PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human ACMSD. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ACMSD antibody, picolinate carboxylase antibody, 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase antibody, aminocarboxymuconate semialdehyde decarboxylase antibody

Background

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM]

Database

Research Area

DATA IMAGES
GTX106739_40135_WB_M_brain_19011506_800.jpg

GTX106739 WB Image

Sample (50 ug of whole cell lysate)
A: Mouse brain
10% SDS PAGE
GTX106739 diluted at 1:1000

GTX106739_40135_IHC_19011506_596.jpg

GTX106739 IHC-P Image

Immunohistochemical analysis of paraffin-embedded SAS xenograft, using ACMSD(GTX106739) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX106739_WB_19011506_319.jpg

GTX106739 WB Image

Sample (30 ug of whole cell lysate)
A: Molt-4 (GTX27912)
B: Raji
10% SDS PAGE
GTX106739 diluted at 1:1000

SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 319
$ 169