GeneTex
United States (US)

AChR alpha 10 antibody

CHRNA10-antibody-GTX87783-WB-1_18122102_511.jpg

Cat No. GTX87783

Host Rabbit
Clonality Polyclonal
Application WB, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

49 kDa. ( Note )

Specificity/Sensitivity

CHRNA10 Antibody detects endogenous levels of total CHRNA10 protein.
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human CHRNA10.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Neuronal acetylcholine receptor subunit alpha-10, Neuronal acetylcholine receptor subunit alpha10, Nicotinic acetylcholine receptor subunit alpha10, Nicotinic acetylcholine receptor subunit alpha 10, NACHR alpha10, CHRNA10, NACHR alpha 10

Background

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
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Database

Research Area

DATA IMAGES
CHRNA10-antibody-GTX87783-WB-1_18122102_511.jpg

GTX87783 WB Image

Western blot analysis of extracts from HeLa/293/COLO/A549 cells, using CHRNA10 Antibody. The lane on the right is treated with the synthesized peptide.