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ADAM10 peptide

Cat No. GTX27868

Application

Neutralizing/Inhibition

Species

Human
Package
50 μg ($139)

APPLICATION

Application Note

The peptide is used for blocking the activity of anti-ADAM10.Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocksthe antibody activity in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, 10mM NaH₂PO₄, 10mM Na₂HPO₄, 130mM NaCl, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Adam Metallopeptidase Domain 10 , Ad10 , Ad18 , Cd156C , Cdw156 , Hst18717 , Madm , Rak , Kuz , Adam10

Background

Proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-alpha, Notch and its ligand Delta are all membrane bound molecules, which are cleaved by proteases. ADAM10, a metalloprotease-disintegrin from the family of mammalian ADAMs (a disintegrin and metalloprotease), cleaves amyloid plaque protein, TNF-alpha, Notch, and its ligand Delta. ADAM10 contains the canonical HExxHxxxxxH zinc metalloproteinase motif. In bovine kidney, ADAM10 cleaves Type IV collagen. ADAM10 is efficiently inhibited by the endogenous MMP inhibitors TIMP1 and TIMP3, but not by TIMP2 and TIMP4. ADAM10 is widely expressed in tissues and can be found on the cell surface and within the cell. The genes encoding human, mouse and bovine ADAM10 are designated ADAM10, kuzbanian (KUZ), and MADM respectively and have 97% sequence identity with each other and with rat ADAM10. There is 45% identity between mouse and Drosophila.

Research Area

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139