APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1:500~1:1000 |
Not tested in other applications.
Calculated MW
Product Note
ADAM17 (cleaved Arg215) antibody detects endogenous levels of fragment of activated ADAM 17 resulting from cleavage adjacent to Arg215.
PROPERTIES
Form
Liquid
Buffer
PBS, 150mM NaCl, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human ADAM17 (196-245).
Purification
Purified by antigen-affinity chromatography
From serum
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
ADAM metallopeptidase domain 17 , ADAM17 , ADAM18 , CD156B , CSVP , NISBD , NISBD1 , TACE
Cellular Localization
Membrane
Background
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX86885 WB Image
WB analysis of rat liver cell lysates using GTX86885 ADAM17 (cleaved Arg215) antibody. The lane on the right is blocked with the synthesized peptide.
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REFERENCE
There are currently no references for ADAM17 (cleaved Arg215) antibody (GTX86885). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for ADAM17 (cleaved Arg215) antibody (GTX86885). Be the first to share your experience with this product.