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ADAM17 peptide

Cat. No. GTX27881

Application

 Neutralizing/Inhibition

Species

 Human
Package
50 μg ($139)
See all ADAM17 products

APPLICATION

Application Note

The peptide is used for blocking the activity of anti-TACE (GTX22051).Incubating the peptide with equal volume of antibody for 30 min at 37ºC usually completely blocksthe activity of anti-TACE in Western blotting.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store the peptide at -20ºC, stable for one year.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Adam Metallopeptidase Domain 17 , Adam18 , Cd156B , Csvp , Nisbd , Nisbd1 , Tace , Adam17

Background

TNF alpha is a pro-inflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. It is synthesized as a 26K type II membrane-bound precursor that is cleaved by aconvertase to generate secreted 17K mature TNF alpha. TNF alpha converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGF alpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.

Research Area

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 139