*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Human, Rat, Bovine(>80% identity)
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Recombinant protein encompassing a sequence within the center region of human ADAMTS4. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ADAMTS-2 antibody, ADAMTS-4 antibody, ADMP-1 antibody, KIAA0688 antibody, ADAMTS4 antibody, ADAM-TS4 antibody, "a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 antibody", A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody, aggrecanase-1 antibody, ADAM-TS 4 antibody, "ADAM metallopeptidase with thrombospondin type 1 motif, 4 antibody"
Secreted , extracellular space , extracellular matrix
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq]