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ADAMTS4 antibody

Anti-ADAMTS4 antibody used in IHC (Paraffin sections) (IHC-P). GTX78143
Anti-ADAMTS4 antibody used in IHC (Paraffin sections) (IHC-P). GTX78143
Anti-ADAMTS4 antibody used in IHC (Paraffin sections) (IHC-P). GTX78143

Cat No. GTX78143

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Human, Mouse, Bovine, Dog, Hamster, Guinea pig, Monkey, Bat, Horse
Package
25 μg ($269)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 2 μg/ml
Not tested in other applications.

Calculated MW

90 kDa. ( Note )

Predict Reactivity

Rat, Pig, Elephant, Gibbon, Marmoset, Opossum, Orangutan, Panda(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 15 amino acid peptide from Disintegrin-like domain of human ADAMTS4.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_425091

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ADAM metallopeptidase with thrombospondin type 1 motif 4 , ADAMTS2 , ADAMTS4 , ADMP1 , ADAMTS-4

Cellular Localization

Secreted,Extracellular space,Extracellular matrix

Background

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-ADAMTS4 antibody used in IHC (Paraffin sections) (IHC-P). GTX78143

GTX78143 IHC-P Image

IHC-P analysis of human cartilage tissue using GTX78143 ADAMTS4 antibody.
Antigen retrieval : Heat-induced antigen retrieval

Anti-ADAMTS4 antibody used in IHC (Paraffin sections) (IHC-P). GTX78143

GTX78143 IHC-P Image

IHC-P analysis of human skin, melanoma tissue using GTX78143 ADAMTS4 antibody.
Antigen retrieval : Heat-induced antigen retrieval

Anti-ADAMTS4 antibody used in IHC (Paraffin sections) (IHC-P). GTX78143

GTX78143 IHC-P Image

IHC-P analysis of human kidney tissue using GTX78143 ADAMTS4 antibody.
Antigen retrieval : Heat-induced antigen retrieval

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 269