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AGTR1 antibody [EPR3873]

Anti-AGTR1 antibody [EPR3873] used in Western Blot (WB). GTX63229

Cat. No. GTX63229

Reference 1

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 EPR3873

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all AGTR1 products

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1:1,000 - 10,000
Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

41 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

50mM Tris-Glycine, 150mM NaCl, 0.05% BSA, 40% Glycerol

Preservative

0.01% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to residues on the N-terminus in human Type-1 Angiotensin II receptor was used as an immunogen.

Purification

Tissue culture supernatant

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,488.

TARGET

Synonyms

angiotensin II receptor type 1 , AG2S , AGTR1B , AT1 , AT1AR , AT1B , AT1BR , AT1R , AT2R1 , HAT1R

Cellular Localization

Cell membrane; Multi-pass membrane protein

Background

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

Database

Research Area

DATA IMAGES

Anti-AGTR1 antibody [EPR3873] used in Western Blot (WB). GTX63229

GTX63229 WB Image

Western blot analysis on (A) C2C12, (B) PC-12, (C) HeLa, and (D) HepG2 cell lysates using anti-Type-1 Angiotensin II receptor RabMAb (cat. #GTX63229).

REFERENCE

Application Reference

Yoshihara T et al. J Physiol Sci 2022; 72 (1) : 6 Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-β signaling.
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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399