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AIRE antibody

Anti-AIRE antibody used in Western Blot (WB). GTX04257
Anti-AIRE antibody used in IHC (Paraffin sections) (IHC-P). GTX04257
Anti-AIRE antibody used in Western Blot (WB). GTX04257
Anti-AIRE antibody used in Western Blot (WB). GTX04257

Cat. No. GTX04257

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse
Package
100 μl ($499)
See all AIRE products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

58 kDa. ( Note )

Predict Reactivity

Rat, Bovine, Dog, Guinea pig, Horse(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 2% sucrose

Preservative

0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

autoimmune regulator , AIRE1 , APECED , APS1 , APSI , PGA1

Cellular Localization

Nucleus , Cytoplasm

Background

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]

Database

DATA IMAGES

Anti-AIRE antibody used in Western Blot (WB). GTX04257

GTX04257 WB Image

WB analysis of human lymphoblastoid cell lysates using GTX04257 AIRE antibody.
Dilution : 1:1000

Anti-AIRE antibody used in IHC (Paraffin sections) (IHC-P). GTX04257

GTX04257 IHC-P Image

IHC-P analysis of human kidney tissue using GTX04257 AIRE antibody.
Dilution : 4-8 μg/ml

Anti-AIRE antibody used in Western Blot (WB). GTX04257

GTX04257 WB Image

WB analysis of mouse skeletal muscle tissue lysates using GTX04257 AIRE antibody.
Dilution : 1 μg/mL

Anti-AIRE antibody used in Western Blot (WB). GTX04257

GTX04257 WB Image

WB analysis of human liver tissue lysates using GTX04257 AIRE antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 499