GeneTex
United States (US)

AKAP12 antibody

Cat No. GTX10346

Host Sheep
Clonality Polyclonal
Isotype IgG
Application WB, IP
Reactivity Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 2-5 μg/ml
IP 2-5 μg/ml

Note :

IP
Using in the presence of 100 ng/ml of human recombinant eotaxin-2.

Not tested in other applications.

Calculated MW

181 kDa. ( Note )

Positive Control

rat aortic smooth muscle
PROPERTIES

Form

Liquid

Buffer

PBS, 0.08% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Rat

Immunogen

rat SSeCKS.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Background

SSeCKS (Src Suppressed C Kinase Substrate) is a major protein kinase C substrate with tumor suppressor activity in models of src- and ras-induced oncogenic transformation. SSeCKS regulates actin-based cytoskeletal and tissue architecture, as well as kinases such as protein kinase C (PKC), protein kinase A (PKA) and calmodulin. Additionally, SSeCKS, has been implicated in the formation of migratory processes and cell migration during embryogenesis. Rat SSeCKS shares extensive homology with human Gravin, an autoantigen in myasthenia gravis that encodes kinase scaffolding functions and whose expression pattern in fibroblasts and nerves suggests a role in cell motility.

Database

Package List Price ($)
$ 319