APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
0.2-2μg/ml |
Assay dependent |
0.2- 2μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Rabbit, Dog, Chicken, Guinea pig, Pig, Monkey, Japanese Medaka, Chimpanzee, Gorilla, Horse, Orangutan, Panda, Turkey, West Indian ocean coelacanth, Nile tilapia, Duckbill platypus, Three-spined stickleback(>80% identity)
PROPERTIES
Form
Liquid
Buffer
Tris-Citrate/Phosphate
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide representing a portion of the protein encoded within exon 8.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
RRID
AB_367630
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
AMPK , AMPKa1 , PRKAA1 , protein kinase AMPactivated catalytic subunit alpha 1 , AMPK alpha 1 , protein kinase AMP-activated catalytic subunit alpha 1
Cellular Localization
Cytoplasm,Nucleus
Background
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX23759 WB Image
WB analysis of (1) bovine aortic endothelial cell, (2) rat aortic smooth muscle cell, (3) HepG2 cell, and (4) human aortic endothelial cell lysates using GTX23759 AMPK alpha 1 antibody. Dilution : 2μg/ml
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REFERENCE
REVIEW
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