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AMPK alpha 2 antibody

Cat. No. GTX23760

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IP

Reactivity

 Human, Mouse, Rat, Bovine
Package
50 μl ($399)
See all AMPK alpha 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.2-2μg/ml
IP Assay dependent
Not tested in other applications.

Calculated MW

62 kDa. ( Note )

Product Note

The epitope recognized is in the region between aa 350 and 400 of AMPK alpha-2.

Predict Reactivity

Rabbit, Guinea pig, Pig, Monkey, Chimpanzee, Gorilla, Orangutan, Chinese Hamster, Northern white-cheeked gibbon, crab-eating macaque, White-tufted-ear marmoset, African elephant, Naked mole rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

Tris-Citrate/Phosphate

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide representing a portion of the protein encoded within exon 7.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

AMPK , AMPK2 , AMPKa2 , PRKAA , PRKAA2 , protein kinase AMPactivated catalytic subunit alpha 2 , AMPK alpha 2 , protein kinase AMP-activated catalytic subunit alpha 2

Cellular Localization

Cytoplasm,Nucleus

Background

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399