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APBA2 antibody

Anti-APBA2 antibody used in Western Blot (WB). GTX85144
Anti-APBA2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85144
Anti-APBA2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85144

Cat. No. GTX85144

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μg ($399)
See all APBA2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

83 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

APBA2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APBA2.The immunogen is located within amino acids 290 - 340 of APBA2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

amyloid beta precursor protein binding family A member 2 , D15S1518E , HsT16821 , LIN-10 , MGC:14091 , MINT2 , X11-BETA , X11L

Background

APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimer's disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.

Database

Research Area

DATA IMAGES

Anti-APBA2 antibody used in Western Blot (WB). GTX85144

GTX85144 WB Image

WB analysis of human brain tissue lysate using GTX85144 APBA2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-APBA2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85144

GTX85144 IHC-P Image

IHC-P analysis of human brain tissue using GTX85144 APBA2 antibody.
Working concentration : 10 μg/ml

Anti-APBA2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85144

GTX85144 IHC-P Image

IHC-P analysis of human brain tissue using GTX85144 APBA2 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399