GeneTex
United States (US)

API5 antibody

GTX38554_20190129_WB_19012901_545.jpg
GTX38554_20190129_IHC-P_19012901_106.jpg

Cat No. GTX38554

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Rat
APPLICATION

Calculated MW

59 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.001% Na2HPO4, 0.025% BSA, 0.0045% NaCl, 0.00025% Thimerosal, 0.00025% NaN3

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human API5 (487-504aa KYSSNLGNFNYERSLQGK)(b), different from the related mouse sequence by one amino acid.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Apoptosis Inhibitor 5,Aac-11,Aac11,Api5

Cellular Localization

Cytoplasm,Nucleus

Background

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Database

Research Area

DATA IMAGES
GTX38554_20190129_WB_19012901_545.jpg

GTX38554 WB Image

WB analysis of rat cardiac muscle tissue lysate using GTX38554 API5 antibody.

GTX38554_20190129_IHC-P_19012901_106.jpg

GTX38554 IHC-P Image

IHC-P analysis of human epidermic carcinoma tissue using GTX38554 API5 antibody.

Package List Price ($)
$ 229