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API5 antibody

Anti-API5 antibody used in Western Blot (WB). GTX38554
Anti-API5 antibody used in IHC (Paraffin sections) (IHC-P). GTX38554

Cat. No. GTX38554

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Rat
Package
50 μg ($399)
See all API5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

59 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.001% Na₂HPO₄, 0.0045% NaCl, 0.025% BSA

Preservative

0.00025% Thimerosal, 0.00025% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human API5 (487-504aa KYSSNLGNFNYERSLQGK)(b), different from the related mouse sequence by one amino acid.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

apoptosis inhibitor 5 , AAC-11 , AAC11

Cellular Localization

Nucleus,Cytoplasm

Background

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Database

Research Area

DATA IMAGES

Anti-API5 antibody used in Western Blot (WB). GTX38554

GTX38554 WB Image

WB analysis of rat cardiac muscle tissue lysate using GTX38554 API5 antibody.

Anti-API5 antibody used in IHC (Paraffin sections) (IHC-P). GTX38554

GTX38554 IHC-P Image

IHC-P analysis of human epidermic carcinoma tissue using GTX38554 API5 antibody.

REFERENCE

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REVIEW

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SDS
Thimerosal.pdf
Package List Price ($)
$ 399