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APP antibody [3E9]

Anti-APP antibody [3E9] used in Western Blot (WB). GTX12338

Cat. No. GTX12338

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 3E9

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human, Mouse
Package
50 μg ($399)
See all APP products

APPLICATION

Application Note

IHC-P: Use at a concentration of 5 - 10 μg/ml. WB: Use at a concentration of 5 - 10 μg/ml. Predicted molecular weight: 87 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

87 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 10mg/ml Sucrose

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: LEVPTDGNAGLLAEPQIAMFC , corresponding to amino acids 18-38 of Human Amyloid Precursor Protein.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

amyloid beta precursor protein , AAA , ABETA , ABPP , AD1 , APPI , CTFgamma , CVAP , PN-II , PN2 , preA4

Cellular Localization

Cell membrane , Membrane , Cytoplasmic vesicle , Cytoplasm

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Database

Research Area

DATA IMAGES

Anti-APP antibody [3E9] used in Western Blot (WB). GTX12338

GTX12338 WB Image

Western blot analysis of Amyloid Precursor Protein expression in mouse brain using APP mAb (3E9)

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399