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APP antibody

Anti-APP antibody used in Western Blot (WB). GTX00753
Anti-APP antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00753

Cat No. GTX00753

Host

Rabbit

Clonality

Polyclonal

Application

WB, ICC/IF

Reactivity

Human, Mouse, Rat
Package
100 μl ($359)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
ICC/IF 1:500-1:1000
Not tested in other applications.

Calculated MW

87 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Serum with 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to the N-terminus (aa 18-38) of human APP

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

amyloid beta precursor protein , AAA , ABETA , ABPP , AD1 , APPI , CTFgamma , CVAP , PN-II , PN2 , preA4

Cellular Localization

Cell membrane,Membrane,Cytoplasmic vesicle,Cytoplasm

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Database

Research Area

DATA IMAGES

Anti-APP antibody used in Western Blot (WB). GTX00753

GTX00753 WB Image

WB analysis of mouse embryo (E16.5) using GTX00753 APP antibody.
APP undergoes various post-translational modification such as N- and O-glycosylation, proteolytic cleavage and phosphorylation.
Dilution : 1:500
Loading : 10 μg

Anti-APP antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00753

GTX00753 ICC/IF Image

ICC/IF analysis of mouse dorsal root ganglion cells using GTX00753 APP antibody.
Dilution : 1:500

REFERENCE

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REVIEW

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Package List Price ($)
$ 359