GeneTex
United States (US)

APRIL antibody [Sacha-1]

APRIL-antibody-Sacha-1_FACS_GTX16085-1_18121409_748.jpg
APRIL-antibody-Sacha-1_IHC_GTX16085-1_18121409_961.jpg

Cat No. GTX16085

Host Rat
Clonality Monoclonal
Clone Name Sacha-1
Isotype IgG2a
Application ICC/IF, FACS, IHC
Reactivity Human, Mouse
APPLICATION

Application Note

For FACS: Use at a concentration of 1 μg/ml. For ICC: Use at a concentration of 5 μg/ml. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

27 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline containing 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human APRIL (aa 105-250) fused to human ACRP30headless (aa 16-108)

Purification

>95% by SDS-PAGE

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Superfamily Member 13,April,Cd256,Tall-2,Tall2,Tnlg7B,Trdl-1,Unq383/Pro715,Ztnf2,Tnfsf13

Background

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

Database

DATA IMAGES
APRIL-antibody-Sacha-1_FACS_GTX16085-1_18121409_748.jpg

GTX16085 FACS Image

Monoclonal antibody to APRIL (GTX16085) detects membrane-bound human APRIL by FACS

APRIL-antibody-Sacha-1_IHC_GTX16085-1_18121409_961.jpg

GTX16085 IHC Image

Immunostaining of HEK-293T cells transfected with a mouse APRIL expression plasmid (left panels) or mock transfected (right panel)

Package List Price ($)
$ 319