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ARAP1 antibody [ARAP1-2]

Orthogonal
Anti-ARAP1 antibody [ARAP1-2] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80235

Cat. No. GTX80235

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 ARAP1-2

Isotype

 IgG1

Application

 WB, ICC/IF, IP

Reactivity

 Human
Package
100 μg ($399)
See all ARAP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

162 kDa. ( Note )

Product Note

This antibody reacts with C-terminal part of ARAP1, a 160 kDa adaptor protein.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ARAP1 , ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 , CENTD2

Cellular Localization

Cytoplasm,Golgi apparatus,Golgi stack membrane,Cell membrane

Background

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Database

Research Area

DATA IMAGES

Anti-ARAP1 antibody [ARAP1-2] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX80235

GTX80235 ICC/IF Image

Orthogonal

ICC/IF analysis of methanol-fixed, ARAP1-transfected NCTC cells treated with TRAIL for 0’, 30’ or 60’ using GTX80235 ARAP1 antibody [ARAP1-2]. Arrowheads show ARAP1-DR4 colocalization at the plasma membrane and intracellular membranes, whereas arrows show their colocalization in early endosomes.
Red : DR4
Green : GTX80235

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399