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ARMER antibody

Anti-ARMER antibody used in Western Blot (WB). GTX85516
Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516
Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516

Cat No. GTX85516

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, IHC-Fr, ELISA
Reactivity Human, Mouse, Rat
Package
100 μg ($339)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
IHC-P 2 μg/mL
IHC-Fr Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

23 kDa. ( Note )

Positive Control

Mouse Small Intestine Tissue Lysate(GTX27939)

Specificity/Sensitivity

This antibody is specific for ARMER C-Terminus
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ARMER antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human ARMER.The immunogen is located within the last 50 amino acids of ARMER.

Purification

Purified by ion exchange chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Adp Ribosylation Factor Like Gtpase 6 Interacting Protein 1,Aip1,Arl6Ip,Armer,Spg61,Arl6Ip1

Background

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA (1). Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12 (2), other caspases such as caspase-9 are also thought to be activated following ER stress (3). Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity (3), although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Database

Research Area

DATA IMAGES
Anti-ARMER antibody used in Western Blot (WB). GTX85516

GTX85516 WB Image

WB analysis of mouse small intestine tissue lysate using GTX85516 ARMER antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516

GTX85516 IHC-P Image

IHC-P analysis of mouse intestine tissue using GTX85516 ARMER antibody.
Working concentration : 2 μg/ml

Anti-ARMER antibody used in IHC (Paraffin sections) (IHC-P). GTX85516

GTX85516 IHC-P Image

IHC-P analysis of human bladder tissue using GTX85516 ARMER antibody.
Working concentration : 2 μg/ml

REFERENCE
REVIEW
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Package List Price ($)
$ 339