GeneTex
United States (US)

ARNT2 antibody [N2C1], Internal

GTX115314_40282_WB_M_Brain_18121410_292.jpg

Cat No. GTX115314

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
Not tested in other applications.

Calculated MW

79 kDa. ( Note )

Positive Control

Mouse brain

Predict Reactivity

Human, Rat, Zebrafish, Sheep, Bovine, Xenopus laevis(>80% identity)
PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.47mg/ml

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human ARNT2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

KIAA0307 antibody, bHLHe1 antibody, ARNT2 antibody, aryl hydrocarbon receptor nuclear translocator 2 antibody, class E basic helix-loop-helix protein 1 antibody, ARNT protein 2 antibody, aryl-hydrocarbon receptor nuclear translocator 2 antibody

Cellular Localization

Nucleus

Background

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq]
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Database

Research Area

DATA IMAGES
GTX115314_40282_WB_M_Brain_18121410_292.jpg

GTX115314 WB Image

Sample (50 ug of whole cell lysate)
A: Mouse brain
7.5% SDS PAGE
GTX115314 diluted at 1:1000

SDS
Glycerol.pdf
Thimerosal.pdf