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ARTS antibody

Cat No. GTX10441

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IP
Reactivity Human
Package
50 μl ($329)
See all ARTS products
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:15,000
IP 10μl
Not tested in other applications.

Calculated MW

55 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.01M PBS pH7.4, 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

synthetic peptide corresponding to the C-terminal region of human ARTS (amino acids 247-266 with N-terminal added lysine) conjugated to KLH.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

septin 4 , ARTS , BRADEION , C17orf47 , CE5B3 , H5 , MART , PNUTL2 , SEP4 , hCDCREL-2 , hucep-7

Cellular Localization

Cytoplasm,Cytoplasm, cytoskeleton,Nucleus

Background

Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF beta and, to a lesser extent, by other apoptotic agents, such as TNF alpha and Fas ligand.

Database

Research Area

REFERENCE
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Package List Price ($)
$ 329