GeneTex
United States (US)

ARTS antibody

ARTS-antibody_IHC-P_GTX29651-1_18121409_243.jpg
ARTS-antibody_WB_GTX29651-1_18121409_916.jpg

Cat No. GTX29651

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

Western blot at 0.5 to 2 μg/ml. Human lung, kidney and spleen tissue lysates can be used as a positive control and a band at 32 kDa can be detected.

Calculated MW

55 kDa. ( Note )

Positive Control

Human lung, kidney and spleen tissue lysates.
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide: KRFLEDTTDDGE, corresponding to amino acids 3-14 of Human ARTS.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

hCDCREL2, 603696, hCDCREL-2, H5, hucep-7, 5414, ARTS, O43236, hucep7, SEPT4, PNUTL2, CE5B3, hucep 7, hCDCREL 2

Cellular Localization

Mitochondrial and Nuclear

Background

Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway (1). ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene (1-4) is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-b and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.

Database

Research Area

DATA IMAGES
ARTS-antibody_IHC-P_GTX29651-1_18121409_243.jpg

GTX29651 IHC-P Image

Immunohistochemical staining of ARTS in human lung tissue with ARTS antibody (GTX29651) at 2μg/ml.

ARTS-antibody_WB_GTX29651-1_18121409_916.jpg

GTX29651 WB Image

Western blot analysis of ARTS expression in human lung (lane 1),spleen (lane 2), and kidney (lane 3) tissue lysates with ARTS antibody (GTX29651) at 2μg /ml.

Package List Price ($)
$ 329