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ATM antibody [1D1]

Anti-ATM antibody [1D1] used in IHC (Paraffin sections) (IHC-P). GTX34046
Anti-ATM antibody [1D1] used in IHC (Paraffin sections) (IHC-P). GTX34046

Cat No. GTX34046

Host Mouse
Clonality Monoclonal
Clone Name 1D1
Isotype IgG1
Application IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

351 kDa. ( Note )

Specificity/Sensitivity

ATM Mouse Monoclonal Antibody (1D1) detects endogenous levels of ATM
PROPERTIES

Form

Liquid

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant Protein of ATM

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Atm Serine/Threonine Kinase,At1,Ata,Atc,Atd,Atdc,Ate,Tel1,Telo1,Atm

Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

Database

Research Area

DATA IMAGES
Anti-ATM antibody [1D1] used in IHC (Paraffin sections) (IHC-P). GTX34046

GTX34046 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Colon Carcinoma Tissue using ATM Mouse Monoclonal Antibody diluted at 1:200.

Anti-ATM antibody [1D1] used in IHC (Paraffin sections) (IHC-P). GTX34046

GTX34046 IHC-P Image

Immunohistochemistry (IHC) analysis of paraffin-embedded Human Breast Carcinoma Tissue using ATM Mouse Monoclonal Antibody diluted at 1:200.