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ATM antibody [2C1]

KO/KD Orthogonal IP/MS
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Anti-ATM antibody [2C1] used in IHC (Paraffin sections) (IHC-P). GTX70103
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Anti-ATM antibody [2C1] used in IHC (Paraffin sections) (IHC-P). GTX70103
Anti-ATM antibody [2C1] used in IHC (Paraffin sections) (IHC-P). GTX70103
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103

Cat. No. GTX70103

Reference 227
20

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2C1

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, FACS, IP, ELISA, ChIP assay, IHC

Reactivity

 Human, Mouse, Rat, Monkey
Package
100 μl ($399)
See all ATM products
PRODUCT

Summary

ATM antibody [2C1] is a mouse monoclonal antibody developed by Dr. Eva Lee’s lab at the University of Texas Health Science Center at San Antonio (PMID: 8969240). It is a well-validated and highly cited reagent to detect ATM protein, which is a nuclear serine/threonine kinase that plays a pivotal role in DNA damage sensing and repair.

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at a dilution of 1:500-1:3000. Predicted 350 kDa.
For IHC-P: Use at 5 μg/mL. Antigen retrieval in Citrate buffer is recommended.
For IP: Use at a concentration of 1-10 μg/ml.
For ICC/IF: Please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006.
For FACS:Use at an dependent assay. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

351 kDa. ( Note )

Positive Control

SK-N-SH , HeLa , HeLa nuclear extract

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.

Purification

Purified by antigen-affinity chromatography.
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_368161

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ATM serine/threonine kinase , AT1 , ATA , ATC , ATD , ATDC , ATE , TEL1 , TELO1

Cellular Localization

Nucleus , Cytoplasmic vesicle

Background

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

Database

Research Area

DATA IMAGES

Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103

GTX70103 WB Image

KO/KD

Non-transfected (–) and transfected (+) HeLa whole cell extracts (60 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103

GTX70103 WB Image

Orthogonal

Untreated (–) and treated (+) 293T whole cell extracts (60 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Anti-ATM antibody [2C1] used in IHC (Paraffin sections) (IHC-P). GTX70103

GTX70103 IHC-P Image

Human Testis (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103

GTX70103 WB Image

Detection of human ATM protein using anti-ATM 2C1 monoclonal antibody (GTX70103) by western blot or immunoprecipitation.
Anti-ATM antibody [2C1] used in IHC (Paraffin sections) (IHC-P). GTX70103

GTX70103 IHC-P Image

Human Kidney (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-ATM antibody [2C1] used in IHC (Paraffin sections) (IHC-P). GTX70103

GTX70103 IHC-P Image

ATM antibody [2C1] detects ATM protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
ATM stained by ATM antibody [2C1] (GTX70103) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103

GTX70103 WB Image

Whole cell extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:1000.

Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103

GTX70103 WB Image

Orthogonal

HeLa whole cell extract and nuclear extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

REFERENCE

Application Reference

Sible E et al. J Immunol 2023; 210 (4) : 369-376 Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination.
Li J et al. Nucleic Acids Res 2022; 50 (18) : 10503-10525 APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus.
Zhang Y et al. iScience 2022; 25 (10) : 105115 RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11.
Kim YH et al. Cells 2022; 11 (18) Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation.
Fangfang Wang et al. Acta Pharm Sin B 2022; 12 (3) : 1339-1350 Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR.
Application : WB
Reactivity : Human
Show More +
Submit a Reference

REVIEW

ATM antibody [2C1] Cat. No. GTX70103

Rating
( Average 5 based on 20 users reviews)
Application
Western Blot(WB)
( Average 5 based on 18 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 5 based on 2 users reviews)
Immunoprecipitation(IP)
( Average 5 based on 2 users reviews)
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2014.PMID: 25105411
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Figure Note : The data was peer reviewed and published in the journal J Biol Chem in 2013.PMID: 23525106
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2018.PMID: 29410405
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2017.PMID: 28031537
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2017.PMID: 28031537
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2018.PMID: 29410405
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Molecules in 2019.PMID: 31269698
Anti-ATM antibody [2C1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70103
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : ICC/IF
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Nucleic Acids Res in 2016.PMID: 26424850
Anti-ATM antibody [2C1] used in Western Blot and Immunoprecipitation (WB IP). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB,IP
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2013. PMID: 24086335
Anti-ATM antibody [2C1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : ICC/IF
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2013. PMID: 24086335
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2016. PMID: 27074761
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Mol Cancer in 2010. PMID: 20356374
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2014. PMID: 24933654
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2013. PMID: 24086335
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu, Ms
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2013. PMID: 23667485
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2015. PMID: 25826455
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Cell Res in 2018. PMID: 29844578
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2015. PMID: 25826455
Anti-ATM antibody [2C1] used in Western Blot (WB). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Aging Cell in 2015. PMID: 25645366
Anti-ATM antibody [2C1] used in Western Blot and Immunoprecipitation (WB IP). GTX70103
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB,IP
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Cell Res in 2018. PMID: 29844578
Show More +
Submit a Review
Application Reference
Sible E et al. J Immunol 2023; 210 (4):369-376 Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination.
Li J et al. Nucleic Acids Res 2022; 50 (18):10503-10525 APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolus.
Zhang Y et al. iScience 2022; 25 (10):105115 RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11.
Kim YH et al. Cells 2022; 11 (18) Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation.
Fangfang Wang et al. Acta Pharm Sin B 2022; 12 (3):1339-1350 Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR.
Application : WB
Reactivity : Human
Yang SC et al. Int J Mol Sci 2022; 23 (3) Different Cell Responses to Hinokitiol Treatment Result in Senescence or Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Zhang L et al. Nat Commun 2022; 13 (1):360 53BP1 regulates heterochromatin through liquid phase separation.
Reactivity : Human
Bulut-Karslioglu A et al. Nat Commun 2021; 12 (1):4859 Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells.
Application : WB
Reactivity : Mouse
Teng YN et al. Cells 2021; 10 (6) Etoposide Triggers Cellular Senescence by Inducing Multiple Centrosomes and Primary Cilia in Adrenocortical Tumor Cells.
Application : WB
Reactivity : Mouse
Chen TY et al. Cell Death Differ 2021; (Epub) Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response.
Application : WB
Reactivity : Human
Saito Y et al. J Cell Sci 2020; 133 (12) RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner.
Pan YR et al. Biomolecules 2020; 10 (11) ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner.
Application : ICC/IF
Reactivity : Human
Geng X et al. Biochem Pharmacol 2020; 182:114226 Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction.
Application : WB
Reactivity : Human
Wang CY et al. Drug Des Devel Ther 2020; 14:2987-3000 Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis.
Application : WB
Reactivity : Human
Jo DS et al. Autophagy 2020;:1-15 Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy.
Application : WB
Reactivity : Human
Jingwen Li et al. RSC Adv 2019; 9 (67):39082-39089 New spirobisnaphthalenes from an endolichenic fungus strain CGMCC 3.15192 and their anticancer effects through the P53-P21 pathway.
Application : WB
Reactivity : Human
Tang M et al. Sci Adv 2019; 5 (3):eaav1118 SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
Lu X et al. Nucleic Acids Res 2019; 47 (21):10977-10993 GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival.
Application : WB
Reactivity : Human
Bakkenist CJ et al. DNA Repair (Amst) 2019; 80:1-7 Quantitative analysis of ATM phosphorylation in lymphocytes.
Reactivity : Human
Shen TS et al. Molecules 2019; 24 (13) Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation.
Application : WB
Reactivity : Human
Shen M et al. J Exp Clin Cancer Res 2019; 38 (1):149 Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.
Application : WB
Reactivity : Human
Gupta R et al. J Immunol 2019; 202 (10):2924-2944 Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins.
Application : WB, FACS
Reactivity : Human
Tu HJ et al. Clin Epigenetics 2018; 10 (1):162 The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Application : WB
Reactivity : Human
Chen CC et al. Cancers (Basel) 2018; 10 (9) Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair.
Application : WB
Reactivity : Human
Liu Q et al. bioRxiv 2018; (Epub) Subjugation of TGFβ Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining.
Application : WB
Reactivity : Human
Li Z et al. Cell Res 2018; (Epub) Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.
Application : WB
Reactivity : Human
Karlin J et al. Mol Cancer Ther 2018; (Epub) Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice.
Gu X et al. Toxicol Lett 2018; (Epub) Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Application : WB, IP
Reactivity : Human
Chen XF et al. EMBO Rep 2018; (Epub) SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Application : WB
Reactivity : Human
Li FL et al. Nat Commun 2018; 9 (1):508 acetylation accumulates pfkfb3 in cytoplasm to promote glycolysis and protects cells from *-induced apoptosis.
Application : WB
Reactivity : Human
Molenaar RJ et al. Clin Cancer Res 2018; (Epub) IDH1/2 mutations sensitize acute myeloid leukemia to PARP inhibition and this is reversed by IDH1/2-mutant inhibitors.
Application : WB
Reactivity : Human
Vanessa Mordasini et al. Oncotarget 2017; 8 (4):6461-6474 Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells.
Application : WB
Reactivity : Human
Clarke TL et al. Mol Cell 2017; 65 (5):900-916.e7 PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.
Lien WC et al. J Cell Biochem 2017; (Epub) 7-hydroxy-staurosporine, UCN-01, induces DNA damage response and autophagy in human osteosarcoma U2-OS cells.
Application : WB
Reactivity : Human
Karayazi Atici O et al. Endocrinology 2017; (Epub) ATM is required for the prolactin-induced HSP90-mediated increase in cellular viability and clonogenic growth after DNA damage.
Z Chen et al. Hum. Mol. Genet. 2017; (Epub) LRRK2 Interacts with ATM and Regulates Mdm2-p53 Cell Proliferation Axis in Response to Genotoxic Stress.
Dyer LM et al. Breast Cancer Res Treat 2017; (Epub) ATM is required for SOD2 expression and homeostasis within the mammary gland.
Application : WB
Reactivity : Human
Enari M et al. Methods Mol Biol 2017; 1599:145-156 Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS).
Mai Y et al. Blood 2016; 128 (24):2797-2807 an oxidative stress-based mechanism of * cytotoxicity suggests new therapeutic strategies in abc-dlbcl.
Application : WB
Reactivity : Human
Yang Z et al. Sci Transl Med 2016; 8 (331):331ra38 Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
Application : WB
Reactivity : Human
Salzman DW et al. Nat Commun 2016; 7:10954 miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.
Application : IP
Reactivity : Human
Kuo CY et al. Cell Cycle 2016; 15 (6):787-98 RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
Application : WB
Reactivity : Human
Wang Y et al. Genes Dev 2016; 30 (3):293-306 A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.
Application : WB
Reactivity : Human
Federico MB et al. PLoS Genet 2016; 12 (1):e1005792 Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.
Application : WB
Reactivity : Human
You J et al. Cancer Lett 2016; (Epub) SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
Application : WB
Reactivity : Human
Mehta M et al. Oncotarget 2016; HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy.
Application : WB
Reactivity : Human
Inoue S et al. Cancer Cell 2016; 30 (2):337-48 Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Application : WB
Reactivity : Mouse
He D et al. Sci Rep 2016; 6:24504 The dynamic behavior of Ect2 in response to DNA damage.
Application : WB
Reactivity : Mouse
Zhang J et al. Nat Cell Biol 2015; 17 (10):1259-1269 ATM functions at the peroxisome to induce pexophagy in response to ROS.
Application : WB
Reactivity : Human
Gibbs-Seymour I et al. Aging Cell 2015; 14 (2):162-9 Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
Application : WB
Reactivity : Human
Burla R et al. PLoS Genet 2015; 11 (6):e1005167 AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Application : WB
Reactivity : Human
Bakkenist CJ et al. Oncoscience 2015; 2 (5):542-54 A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.
Application : WB
Reactivity : Human
Zellweger R et al. J Cell Biol 2015; 208 (5):563-79 Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
Kijas AW et al. Nucleic Acids Res 2015; 43 (17):8352-67 ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Application : WB
Reactivity : Human
Chou WC et al. Carcinogenesis 2015; 36 (8):832-40 Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
Application : WB
Reactivity : Human
Saquilabon Cruz GM et al. Nucleic Acids Res. 2015; (Epub) Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.
Application : ICC/IF
Reactivity : Human
Nakajima NI et al. PLoS One 2015; 10 (3):e0122582 Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
Application : ICC/IF, IHC
Reactivity : Human
Ruan X et al. J Mol Cell Biol 2015; 7 (2):105-18 P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.
Application : WB
Reactivity : Human
Kumari A et al. DNA Repair (Amst) 2015; 28:73-82 BLM protein mitigates formaldehyde-induced genomic instability.
Application : WB
Reactivity : Human
Ray Chaudhuri A et al. Mol Cell Biol 2015; 35 (5):856-65 Poly(ADP-Ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.
Application : WB
Reactivity : Human
Shisuo Du et al. International Journal of Radiation Oncology*Biology*Physics 2015; 1 (91):91-99 Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non–Small-Cell Lung Cancer Cells In-Vitro and In-Vivo?
Application : WB
Reactivity : Human
Guo J et al. PLoS One 2014; 9 (2):e88140 Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.
Application : WB
Reactivity : Human
Kuo CY et al. J Biol Chem 2014; 289 (30):20757-72 An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Kruppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.
Application : WB
Reactivity : Human
Werner E et al. PLoS One 2014; 9 (10):e108234 Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.
Application : WB
Reactivity : Human
So EY et al. Cell Death Dis 2014; 5:e1418 Translational initiation regulated by ATM in dendritic cells development.
Application : WB
Reactivity : Mouse
Ouchi M et al. Cancer Biol Ther 2014; 15 (12):1700-4 Distinct DNA damage determines differential phosphorylation of Chk2.
Application : WB
Reactivity : Human
Ayrapetov MK et al. Proc Natl Acad Sci U S A 2014; 111 (25):9169-74 DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.
Sajish M et al. Nature 2014; (Epub) A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Application : WB
Reactivity : Human
Du F et al. Biochem Biophys Res Commun 2014; 452 (4):1034-9 Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair.
Application : WB
Reactivity : Human
Hennig J et al. Cell Death Dis 2014; 5:e1199 APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.
Application : ICC/IF
Reactivity : Human
Kotov IN et al. Mol Oncol 2014; Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.
Application : WB
Reactivity : Human
Li LH et al. PLoS One 2014; 9 (8):e104203 hinokitiol induces dna damage and autophagy followed by cell cycle arrest and senescence in *-resistant lung adenocarcinoma cells.
Application : WB
Reactivity : Human
Lim YC et al. Mol Oncol 2014; (Epub) Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells
Application : WB
Reactivity : Human
Lee JH et al. PLoS One 2014; 9 (6):e97969 Direct Activation of ATM by Resveratrol under Oxidizing Conditions.
Application : WB
Reactivity : Human
Wang CY et al. Oncogene 2014; DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
Application : WB
Reactivity : Human
Sharma NK et al. DNA Repair (Amst) 2014; 13:22-31 Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.
Application : WB
Reactivity : Human
Biddlestone-Thorpe L et al. Clin Cancer Res 2013; 19 (12):3189-200 ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.
Application : WB
Reactivity : Human
Lim HC et al. PLoS One 2013; 8 (9):e74334 Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.
Cottarel J et al. J Cell Biol 2013; 200 (2):173-86 A noncatalytic function of the ligation complex during nonhomologous end joining.
Application : WB
Reactivity : Human
Murad NA et al. Mitochondrion 2013; 13 (3):235-45 Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Application : WB
Reactivity : Human
Bowen C et al. Cell Rep 2013; 4 (3):516-29 Functional activation of ATM by the prostate cancer suppressor NKX3.1.
Application : WB
Reactivity : Human
Tripathi DN et al. Proc Natl Acad Sci U S A 2013; 110 (32):E2950-7 Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
Application : WB
Reactivity : Human
Zhang X et al. PLoS One 2013; 8 (5):e62527 Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential.
Application : WB
Reactivity : Human
Lee JH et al. J Biol Chem 2013; 288 (18):12840-51 Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
Application : WB
Stewart R et al. Hum Mol Genet 2013; 22 (12):2495-509 A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
Wu CW et al. PLoS One 2013; 8 (2):e57036 MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer.
Application : WB
Reactivity : Human
Choi SY et al. Nucleic Acids Res 2013; 41 (4):2180-90 Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress.
Application : WB
Reactivity : Human
Shi Y et al. BMC Cancer 2012; 12:571 starvation-induced activation of atm/chk2/p53 signaling sensitizes cancer cells to *.
Application : WB
Reactivity : Human
Nayler S et al. Stem Cells Transl Med 2012; 1 (7):523-35 Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype.
Application : WB
Reactivity : Human
Sakasai R et al. Genes Cells 2012; 17 (12):962-70 CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Application : WB
Reactivity : Human
Dellago H et al. Aging (Albany NY) 2012; 4 (4):290-304 ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Ai L et al. J Biol Chem 2012; 287 (22):18330-41 Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Application : WB
Reactivity : Human
Zhang J et al. Proc Natl Acad Sci U S A 2012; 109 (16):E926-33 Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Kang MA et al. J Biol Chem 2012; 287 (20):16246-55 Deregulation of DNA damage response pathway by intercellular contact.
Application : WB
Hao Z et al. J Exp Med 2012; 209 (1):173-86 The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Shi Y et al. PLoS One 2012; 7 (9):e45354 differential effects of * on * responses in normal human mesothelial cells versus cancer cells: implication for therapy.
Application : WB
Reactivity : Human
Baritaud M et al. Cell Death Dis 2012; 3:e390 AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
Application : WB
Hardee ME et al. Cancer Res 2012; 72 (16):4119-29 Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
Application : WB
Reactivity : Human
Mahajan K et al. J Biol Chem 2012; 287 (26):22112-22 Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
Application : WB
Reactivity : Mouse
Hsu CC et al. J Biol Chem 2012; 287 (27):22533-48 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
Application : WB
Sugimoto N et al. J Biol Chem 2011; 286 (45):39200-10 Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
Brown JA et al. Mol Cell Biol 2011; 31 (22):4417-29 A novel role for hSMG-1 in stress granule formation.
Application : WB
Luo K et al. J Biol Chem 2011; 286 (32):28192-9 Oligomerization of MDC1 protein is important for proper DNA damage response.
Application : IP
Bouquet F et al. J Cell Sci 2011; 124 (Pt 11):1943-51 A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Application : WB
Reactivity : Human
Chen Y et al. Cell Cycle 2011; 10 (4):655-63 Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Application : WB
Reactivity : Human
Matsumoto Y et al. DNA Repair (Amst) 2011; 10 (3):314-21 Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Application : WB
Reactivity : Human
Xu Y et al. Int J Biochem Mol Biol 2011; 2 (4):295-302 The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase.
Application : WB
Reactivity : Human
Assaily W et al. Mol Cell 2011; 44 (3):491-501 ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Application : WB
Reactivity : Mouse
Hada M et al. Mutat Res 2011; 716 (43102):76-83 AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Application : WB
Reactivity : Human
Gatei M et al. J Biol Chem 2011; 286 (36):31542-56 ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Application : WB
Reactivity : Human
Shouse GP et al. Oncogene 2011; 30 (35):3755-65 ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
Application : WB
Reactivity : Human
Cherubini G et al. Nucleic Acids Res 2011; 39 (13):5459-73 The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
Application : WB
Reactivity : Human
Urquhart AJ et al. Genome Integr 2011; 2 (1):1 ATM mediated phosphorylation of CHD4 contributes to genome maintenance.
Application : WB
Reactivity : Human
Ruiz Z et al. Virology 2011; 410 (2):375-84 Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM).
Kozlov SV et al. J Biol Chem 2011; 286 (11):9107-19 Autophosphorylation and ATM activation: additional sites add to the complexity.
Application : WB
Reactivity : Human
Xu Y et al. J Cell Biol 2010; 191 (1):31-43 The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
Application : WB
Reactivity : Human
Huang QM et al. Cancer Res 2010; 70 (21):8407-16 Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.
Application : WB
Storch K et al. Cancer Res 2010; 70 (10):3925-34 Three-dimensional cell growth confers radioresistance by chromatin density modification.
Application : WB
Reactivity : Human
Bowen C et al. Cancer Res 2010; 70 (8):3089-97 NKX3.1 activates cellular response to DNA damage.
Application : ICC/IF
Reactivity : Human
Kongruttanachok N et al. Mol Cancer 2010; 9:70 Replication independent DNA double-strand break retention may prevent genomic instability.
Application : WB
Reactivity : Human
Sakasai R et al. DNA Repair (Amst) 2010; 9 (1):76-82 Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.
Application : WB
Reactivity : Human
Papp LV et al. Antioxid Redox Signal 2010; 12 (7):797-808 SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.
Application : WB
Reactivity : Human
Guo Z et al. Cell Cycle 2010; 9 (24):1061336 ATM activation in the presence of oxidative stress.
Application : WB
Powell MD et al. Proteomics Clin Appl 2010; 4 (3):337-51 Discovery of putative oocyte quality markers by comparative ExacTag proteomics.
Application : ICC/IF
Shanware NP et al. PLoS One 2010; 5 (8):e12173 Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.
Application : WB
Reactivity : Human
Lee JH et al. Proc Natl Acad Sci U S A 2010; 107 (33):14639-44 Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Application : WB
Reactivity : Human
Fang Z et al. Genome Integr 2010; 1 (1):9 Low levels of ATM in breast cancer patients with clinical radiosensitivity.
Application : IP
Reactivity : Human
Ousset M et al. Cell Cycle 2010; 9 (14):2814-22 Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.
Application : WB
Reactivity : Human
Sakasai R et al. J Biol Chem 2010; 285 (20):15201-8 Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Application : WB
Reactivity : Human
Wilhelm MT et al. Genes Dev 2010; 24 (6):549-60 Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Application : WB
Kodama M et al. Mol Cell Biol 2010; 30 (7):1620-33 Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Application : WB
Reactivity : Human
Hu H et al. Proc Natl Acad Sci U S A 2010; 107 (4):1506-11 ATM is down-regulated by N-Myc-regulated microRNA-421.
Application : ELISA
Reactivity : Human
Yoshida K et al. J Cell Sci 2010; 123 (Pt 2):225-35 CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
Application : WB
Reactivity : Human
Bolderson E et al. Nucleic Acids Res 2010; 38 (6):1821-31 Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.
Application : WB
Reactivity : Human
Britton S et al. Cancer Res 2009; 69 (20):2271962 ARTEMIS nuclease facilitates apoptotic chromatin cleavage.
Application : WB
Sun Y et al. Nat Cell Biol 2009; 11 (11):1376-82 Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Application : IP
Reactivity : Human
Sugimoto N et al. J Cell Sci 2009; 122 (Pt 8):1184-91 Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Application : WB
Reactivity : Human
Cui B et al. Mol Pharmacol 2009; 75 (6):1356-63 Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Application : WB
Reactivity : Human
Heffernan TP et al. J Invest Dermatol 2009; 129 (7):1805-15 ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
Application : WB
Reactivity : Human
Hein J et al. J Virol 2009; 83 (1):117-27 Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
Application : WB
Reactivity : Human
Martin LJ et al. Cereb Cortex 2009; 19 (6):1273-93 Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.
Application : WB
So S et al. J Cell Biol 2009; 187 (7):977-90 Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
Application : WB
Reactivity : Human
Nahas SA et al. Clin Chem 2009; 55 (3):463-72 Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Application : ELISA
Reactivity : Human
Chou WC et al. EMBO J 2008; 27 (23):3140-50 Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Application : WB
Reactivity : Human
Meulle A et al. PLoS One 2008; 3 (10):e3345 Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Ariumi Y et al. J Virol 2008; 82 (19):9639-46 The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Application : IP
Reactivity : Human
Stohr BA et al. Cancer Res 2008; 68 (13):5309-17 ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Sugimoto N et al. Mol Biol Cell 2008; 19 (3):1007-21 Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Application : WB
Reactivity : Human
Lai CK et al. Virology 2008; 370 (2):295-309 Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.
Application : IP
Reactivity : Human
Luo H et al. J Biol Chem 2008; 283 (28):19176-83 Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.
Application : WB
Reactivity : Human
Yalcin S et al. J Biol Chem 2008; 283 (37):25692-705 Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Rimkus SA et al. Genes Dev 2008; 22 (9):1205-20 Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.
Wei G et al. Cancer Res 2008; 68 (7):2214-22 Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Application : ICC/IF
Reactivity : Mouse
Sakasai R et al. J Biol Chem 2008; 283 (20):13549-55 RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
Wood JL et al. J Biol Chem 2007; 282 (48):35416-23 MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
Application : WB
Reactivity : Human
Sun Y et al. Mol Cell Biol 2007; 27 (24):2411576 DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Application : IP
Reactivity : Human
Wu X et al. Oncogene 2007; 26 (5):757-64 ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.
Application : WB
Reactivity : Human
Hong X et al. Cancer Res 2007; 67 (15):7165-74 Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors.
Iwahori S et al. J Virol 2007; 81 (18):9653-64 Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein.
Fernandes ND et al. J Biol Chem 2007; 282 (22):16577-84 Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
Application : WB
Reactivity : Human
Inoue Y et al. EMBO J 2007; 26 (8):2083-93 Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
Application : WB
Reactivity : Human
Stauffer D et al. J Biol Chem 2007; 282 (13):9678-87 p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint.
Application : WB
Reactivity : Human
Shi Y et al. J Biol Chem 2007; 282 (12):9236-43 Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
Application : WB
Reactivity : Human
Geng L et al. Mol Cell Biol 2007; 27 (7):2625-35 Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.
Gueven N et al. Neuroscience 2007; 145 (4):1418-25 A subgroup of spinocerebellar ataxias defective in DNA damage responses.
Shanware NP et al. J Biol Chem 2007; 282 (9):6283-91 Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage.
Application : WB
Reactivity : Human
Shreeram S et al. J Exp Med 2006; 203 (13):326407 Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Kirshner J et al. Cancer Res 2006; 66 (22):10861-9 Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
Henderson MJ et al. J Biol Chem 2006; 281 (52):39990-40000 EDD mediates DNA damage-induced activation of CHK2.
Liu Y et al. J Cell Sci 2006; 119 (Pt 22):1002471 DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
Application : ICC/IF
Reactivity : Human
Bai L et al. Gastroenterology 2006; 131 (3):841-52 Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.
Shreeram S et al. Mol Cell 2006; 23 (5):757-64 Wip1 phosphatase modulates ATM-dependent signaling pathways.
Application : IP
Reactivity : Human
Kozlov SV et al. EMBO J 2006; 25 (15):3504-14 Involvement of novel autophosphorylation sites in ATM activation.
Application : WB
Reactivity : Human
Tatsumi Y et al. J Cell Sci 2006; 119 (Pt 15):3128-40 Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
Application : WB
Reactivity : Human
Ahmed KM et al. Mol Cancer Res 2006; 4 (12):945-55 Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.
Application : IP
Reactivity : Human
Jiang X et al. J Biol Chem 2006; 281 (23):15741-6 The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Application : WB
Reactivity : Human
Gueven N et al. Cancer Res 2006; 66 (6):368135 Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Shiotani B et al. Mol Cancer Res 2006; 4 (2):125-33 Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Application : WB
Reactivity : Human
Freiberg RA et al. Mol Cell Biol 2006; 26 (5):1598-609 DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
Application : WB
Reactivity : Human
Aglipay JA et al. J Biol Chem 2006; 281 (14):2852758 ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
Wang HC et al. Cancer Res 2006; 66 (3):1391-400 Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Pusapati RV et al. Proc Natl Acad Sci U S A 2006; 103 (5):1446-51 ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Dodson GE et al. J Biol Chem 2006; 281 (3):1692-7 DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
Application : WB
Reactivity : Human
Gueven N et al. Genes Chromosomes Cancer 2006; 45 (1):61-71 Regulation of the Atm promoter in vivo.
Wang J et al. DNA Repair (Amst) 2005; 4 (5):556-70 Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.
Peng Y et al. Cancer Res 2005; 65 (5):1670-7 Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Li J et al. J Biol Chem 2005; 280 (12):12041-50 Regulation of CHK2 by DNA-dependent protein kinase.
Application : WB
Reactivity : Human
Kudoh A et al. J Biol Chem 2005; 280 (9):8156-63 Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.
Gibson SL et al. Cancer Res 2005; 65 (23):10734-41 Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Application : WB
Reactivity : Human
Shi Y et al. J Biol Chem 2005; 280 (48):40195-200 Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.
Application : IP
Reactivity : Monkey
Sun Y et al. Proc Natl Acad Sci U S A 2005; 102 (37):13182-7 A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Application : IP
Reactivity : Human
Kim JS et al. J Cell Biol 2005; 170 (3):341-7 Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Application : ICC/IF
Reactivity : Human
Young DB et al. J Biol Chem 2005; 280 (30):27587-94 Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Lai CH et al. Proc Natl Acad Sci U S A 2004; 101 (44):15676-81 Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.
Application : IP
Reactivity : Human
Butch AW et al. Clin Chem 2004; 50 (12):147041 Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
Zhang X et al. Mol Cell Biol 2004; 24 (20):9207-20 Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Silverman J et al. Genes Dev 2004; 18 (17):2108-19 Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.
Xu X et al. J Biol Chem 2004; 279 (33):34091-4 Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Dodson GE et al. J Biol Chem 2004; 279 (32):34010-4 DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.
Application : FACS
Reactivity : Human
Fabbro M et al. J Biol Chem 2004; 279 (30):31251-8 BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Dork T et al. Am J Med Genet A 2004; 126A (3):272-7 Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Application : WB
Fujiuchi N et al. J Biol Chem 2004; 279 (19):20339-44 Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation.
Application : WB
Reactivity : Human
Panta GR et al. Mol Cell Biol 2004; 24 (5):1823-35 ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Application : WB
Reactivity : Human
Ali A et al. Genes Dev 2004; 18 (3):249-54 Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
Application : ICC/IF
Reactivity : Human
Qi J et al. Gene Ther 2004; 11 (1):25-33 Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo.
Application : WB
Naka K et al. J Biol Chem 2004; 279 (3):47665 Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
Kozlov S et al. J Biol Chem 2003; 278 (11):9309-17 ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.
Application : WB
Huang TT et al. Cell 2003; 115 (5):565-76 Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.
Application : WB
Reactivity : Human
Shackelford RE et al. DNA Repair (Amst) 2003; 2 (9):971-81 Desferrioxamine treatment increases the genomic stability of Ataxia-telangiectasia cells.
Gueven N et al. Genes Chromosomes Cancer 2003; 38 (2):157-67 Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation.
Application : WB
Reactivity : Human
Cortes ML et al. Gene Ther 2003; 10 (16):1321-7 HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Fedier A et al. Ann Oncol 2003; 14 (6):938-45 Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites.
Kim JS et al. J Biol Chem 2002; 277 (47):45149-53 Specific recruitment of human cohesin to laser-induced DNA damage.
Application : ICC/IF
Reactivity : Human
Zhou XY et al. Oncogene 2002; 21 (41):6377-81 Ku affects the ATM-dependent S phase checkpoint following ionizing radiation.
Application : IP
Reactivity : Mouse
Girard PM et al. Oncogene 2002; 21 (27):837016 Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.
Application : WB
Reactivity : Human
Beamish H et al. J Biol Chem 2002; 277 (34):30515-23 Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.
Scott SP et al. Proc Natl Acad Sci U S A 2002; 99 (2):925-30 Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer.
Perkins EJ et al. Genes Dev 2002; 16 (2):159-64 Sensing of intermediates in V(D)J recombination by ATM.
Application : ChIP assay
Reactivity : Mouse
Dork T et al. Cancer Res 2001; 61 (20):7608-15 Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients.
Smilenov LB et al. Cancer Res 2001; 61 (15):1391635 Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Weil MM et al. Oncogene 2001; 20 (32):916700 Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice.
Application : WB
Reactivity : Mouse
Vemuri MC et al. Cell Death Differ 2001; 8 (3):245-55 Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Application : ICC/IF
Reactivity : Mouse
Hu B et al. J Biol Chem 2001; 276 (21):17693-8 The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway.
Application : WB
Wang Y et al. Genes Dev 2000; 14 (8):927-39 BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Application : WB
Reactivity : Human
Borghesani PR et al. Proc Natl Acad Sci U S A 2000; 97 (7):3336-41 Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
Application : WB
Reactivity : Mouse
Scherthan H et al. Mol Cell Biol 2000; 20 (20):7773-83 Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Application : ICC/IF
Reactivity : Mouse
Chen G et al. J Biol Chem. 1996; 271 (52):33693-7 The product of the ATM gene is a 370-kDa nuclear phosphoprotein.
Application : WB
Reactivity : Human
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