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ATOH8 antibody

Anti-ATOH8 antibody used in IHC (Paraffin sections) (IHC-P). GTX85296
Anti-ATOH8 antibody used in Western Blot (WB). GTX85296

Cat. No. GTX85296

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all ATOH8 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

35 kDa. ( Note )

Positive Control

A20 Cell Lysate(GTX27180)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ATOH8 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATOH8.The immunogen is located within the last 50 amino acids of ATOH8.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

atonal bHLH transcription factor 8 , HATH6 , bHLHa21

Cellular Localization

Nucleus,Nucleus speckle,Cytoplasm

Background

Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43–57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.

Database

Research Area

DATA IMAGES

Anti-ATOH8 antibody used in IHC (Paraffin sections) (IHC-P). GTX85296

GTX85296 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85296 ATOH8 antibody.
Working concentration : 5 μg/ml

Anti-ATOH8 antibody used in Western Blot (WB). GTX85296

GTX85296 WB Image

WB analysis of A-20 cell lysate using GTX85296 ATOH8 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399