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United States (US)

ATR antibody

Cat No. GTX10327

Reference 1
Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human, Mouse
Package
50 μg ($249)
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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.033 - 0.067 μg/ml
Not tested in other applications.

Calculated MW

301 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Tris- citrate/phosphate pH 7-8

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide representing a portion of the protein encoded within exon 29 (LocusLink ID 545).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ATR,ATR serine/threonine kinase,FCTCS,FRP1,MEC1,SCKL,SCKL1

Cellular Localization

Nucleus,PML body,Chromosome

Background

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]

Database

Research Area

REFERENCE

Application Reference

Rankin AM et al. J Cell Physiol 2012; 227 (6) : 2586-94 Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
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REVIEW
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Package List Price ($)
$ 249