Form
Liquid
Buffer
Tris-Citrate/Phosphate
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide representing a portion of the protein encoded within exon 29 (LocusLink ID 545).
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
RRID
AB_1080935
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
ATR , ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1
Cellular Localization
Nucleus,PML body,Chromosome
Background
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
Database
Research Area