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ATR (phospho Thr1989) antibody

KO/KD Orthogonal
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX128145
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Anti-ATR (phospho Thr1989) antibody used in Immunoprecipitation (IP). GTX128145

Cat. No. GTX128145

Reference 82
19

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IP

Reactivity

 Human, Mouse
Package
100 μl ($399),
25 μl ($169)
See all ATR products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IP 1:100-1:500
Not tested in other applications.

Calculated MW

301 kDa. ( Note )

Positive Control

Raji nuclear extract

PROPERTIES

Form

Liquid

Buffer

1XPBS pH7, 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.09 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Thr1989 of human ATR. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2687562

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1

Cellular Localization

Nucleus

Background

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145

GTX128145 WB Image

Orthogonal

Untreated (–) and treated (+) HCT116 whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:2000.

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human esophageal carcinoma.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in human breast carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in human lung by immunohistochemical analysis.
Sample: Paraffin-embedded human lung.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in human colon cancer by immunohistochemical analysis.
Sample: Paraffin-embedded human colon cancer.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR protein at nucleus in human lung cancer by immunohistochemical analysis.
Sample: Paraffin-embedded human lung cancer.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:250.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX128145

GTX128145 ICC/IF Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunofluorescent analysis.
Sample: Mock and treated HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse heart.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:1000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse muscle.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:1000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145

GTX128145 WB Image

Orthogonal

Raji whole cell and nuclear extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human ovarian cancer.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse liver.
ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX128145

GTX128145 ICC/IF Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: ATR (phospho Thr1989) stained by ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:500.
Red: phalloidin, a cytoskeleton marker, diluted at 1:100.

Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145

GTX128145 IHC-P Image

ATR (phospho Thr1989) antibody detects ATR (phospho Thr1989) protein at nucleus in mouse liver by immunohistochemical analysis.
Sample: Paraffin-embedded mouse liver.
ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:200.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145

GTX128145 WB Image

Orthogonal

Untreated (–) and treated (+) HeLa whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with ATR (phospho Thr1989) antibody (GTX128145) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-ATR (phospho Thr1989) antibody used in Immunoprecipitation (IP). GTX128145

GTX128145 IP Image

Immunoprecipitation of ATR (phospho Thr1989) protein from HCT-116 whole cell extracts treated with Hydroxyurea for 6 hr using 5 μg of ATR (phospho Thr1989) antibody (GTX128145).
Western blot analysis was performed using ATR (phospho Thr1989) antibody (GTX128145).
EasyBlot anti-Rabbit IgG (GTX221666-01) was used as a secondary reagent.

REFERENCE

Application Reference

Zhou LL et al. Nat Commun 2023; 14 (1) : 7069 Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.
Ning K et al. Mol Ther Methods Clin Dev 2023; 31 : 101115 Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium.
Xin D et al. Adv Sci (Weinh) 2023; 10 (28) : e2206931 Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response.
Zhou H et al. PLoS Genet 2023; 19 (7) : e1010856 UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1.
Garbarino O et al. Aging Cell 2023; 22 (7) : e13853 Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis.
Show More +
Submit a Reference

REVIEW

ATR (phospho Thr1989) antibody Cat. No. GTX128145

Rating
( Average 5 based on 19 users reviews)
Application
Western Blot(WB)
( Average 5 based on 16 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 5 based on 2 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 1 users reviews)
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 24-Jul-2023
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the 2022 in Sci Rep. PMID: 35361811
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 24-Jul-2023
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the 2022 in Sci Rep. PMID: 35361811
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 24-Jul-2023
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the 2022 in Sci Rep. PMID: 35361811
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 03-Oct-2022
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the 2020 in Nat Commun. PMID: 32796829
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2019.PMID: 31757956
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2018.PMID: 29472538
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Breast Cancer Res in 2017.PMID: 29145865
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS Genet in 2015.PMID: 26684013
Anti-ATR (phospho Thr1989) antibody used in IHC (Paraffin sections) (IHC-P). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC-P
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Inflamm Regen in 2019.PMID: 31057688
Anti-ATR (phospho Thr1989) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : ICC/IF
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal EMBO J in 2018.PMID: 29773570
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2018.PMID: 29472538
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2017.PMID: 28915641
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2017.PMID: 28915641
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Elife in 2019. PMID: 31135337
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Life Sci Alliance in 2018. PMID: 30456359
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS Pathog in 2017. PMID: 28264028
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2017. PMID: 28558031
Anti-ATR (phospho Thr1989) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX128145
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : ICC/IF
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Elife in 2019. PMID: 31135337
Anti-ATR (phospho Thr1989) antibody used in Western Blot (WB). GTX128145
Date : Anonymous submitted on 03-Feb-2016
Score :
Application Tested : WB
Sample Species : Hu
Sample : HT29 cells
Amount used : 20μg
Blocking : 5% milk in PBST, 25°C, 0.5Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Show More +
Submit a Review
Application Reference
Zhou LL et al. Nat Commun 2023; 14 (1):7069 Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.
Ning K et al. Mol Ther Methods Clin Dev 2023; 31:101115 Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium.
Xin D et al. Adv Sci (Weinh) 2023; 10 (28):e2206931 Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response.
Zhou H et al. PLoS Genet 2023; 19 (7):e1010856 UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1.
Tulpule A et al. Res Sq 2023; FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer.
G?der A et al. iScience 2023; 26 (6):106951 PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors.
Garbarino O et al. Aging Cell 2023; 22 (7):e13853 Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis.
Menon S et al. bioRxiv 2023; FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer.
Zhang C et al. Oncogene 2023; 42 (13):967-979 BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance.
Application : WB
Reactivity : Human
Ning K et al. mBio 2023; 14 (1):e0352822 Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication.
Hsiao HW et al. Biomolecules 2023; 13 (1) Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses.
Grange LJ et al. Nat Commun 2022; 13 (1):6664 Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.
Janna Luessing et al. iScience 2022; 25 (7):104536 A function for ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission.
Application : ICC/IF
Reactivity : Human
Tom Egger et al. Sci Rep 2022; 12 (1):5422 A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress.
Maya Raghunandan et al. EMBO J 2021; 40 (6):e106336 NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.
Application : WB
Reactivity : Human
Zhengke Li et al. FASEB J 2021; 35 (5):e21373 ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling.
Application : WB
Reactivity : Human
Gro Elise R?dland et al. Cancers (Basel) 2021; 13 (15) Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells.
Application : WB
Reactivity : Human
Boucher D et al. Sci Rep 2021; 11 (1):20256 hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
Application : WB
Reactivity : Human
Alghoul E et al. STAR Protoc 2021; 2 (3):100677 An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells.
Application : WB
Reactivity : Human
Hernandez Borrero L et al. Elife 2021; 10 A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53.
Application : WB
Reactivity : Human
Ho K et al. Sci Rep 2021; 11 (1):7502 Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress.
Application : WB
Reactivity : Human
Gaillard S et al. Biol Open 2021; 10 (5) KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.
Application : WB
Reactivity : Human
Takeishi Y et al. J Biol Chem 2020; 295 (4):1056-1065 SMARCAD1-mediated recruitment of the DNA mismatch repair protein MutLα to MutSα on damaged chromatin induces apoptosis in human cells.
Wang R et al. Proc Natl Acad Sci U S A 2020; 117 (52):33436-33445 DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress.
Application : WB
Reactivity : Human
Sarker AH et al. Environ Mol Mutagen 2020; 61 (6):635-646 Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells.
Rainey MD et al. Cell Rep 2020; 32 (9):108096 ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.
Application : WB
Reactivity : Human
Lam FC et al. Nat Commun 2020; 11 (1):4083 BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage.
Application : WB
Reactivity : Human
Ito SS et al. J Biol Chem 2020; 295 (37):12946-12961 Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways.
Application : WB
Reactivity : Human
Dunlop CR et al. Br J Cancer 2020;
Application : WB
Reactivity : Human
Zheng T et al. Cell Death Differ 2020; (Epub) RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.
Application : WB
Reactivity : Human
Wang S et al. Cancer Lett 2020; 488:40-49 Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer.
Application : WB
Reactivity : Human
Srivastava M et al. EMBO Rep 2020; 21 (6):e49123 HMCES safeguards replication from oxidative stress and ensures error-free repair.
Application : WB
Reactivity : Human
Andersson MK et al. Oncogenesis 2020; 9 (1):5 ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma.
Application : WB
Reactivity : Human
Rikitake M et al. Genes Cells 2020; (Epub) MLH1-mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O6 -methylguanine.
Application : WB
Reactivity : Human
Yamamoto M et al. Cancer Res 2019; 79 (8):2031-2041 MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells.
Wang C et al. Oncogene 2019; 38 (14):2451-2463 Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.
Kim W et al. Nat Commun 2019; 10 (1):5304 ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.
Application : WB
Reactivity : Human
Tang M et al. Sci Adv 2019; 5 (3):eaav1118 SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.
Fragkos M et al. Oncotarget 2019; 10 (43):4407-4423 Dicer prevents genome instability in response to replication stress.
Application : WB
Reactivity : Human
Bigot N et al. Elife 2019; 8 Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Shaj K et al. Photochem Photobiol 2019; ATR Kinase Activity Limits Mutagenesis and Promotes the Clonogenic Survival of Quiescent Human Keratinocytes Exposed to UVB Radiation.
Hutcherson RJ et al. Mutat Res 2019; 816-818:111678
Application : WB
Hahm ER et al. Mol Carcinog 2019; (Epub)
Application : WB
Reactivity : Human
Matsuno Y et al. Nat Commun 2019; 10 (1):3925 Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro.
Application : WB
Reactivity : Mouse
Combes E et al. Cancer Res 2019; (Epub)
Application : WB
Reactivity : Human
Chen X et al. J Cancer Res Clin Oncol 2019; 145 (6):1471-1484 IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2.
Application : ICC/IF
Reactivity : Human
Watanabe K et al. Inflamm Regen 2019; 39:8 Age-related dysfunction of the DNA damage response in intestinal stem cells.
Application : IHC-P
Reactivity : Mouse
Chou FJ et al. EBioMedicine 2019; 40:504-516 Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression.
Application : WB
Reactivity : Human
Liu H et al. Oncotarget 2018; 9 (4):4318-4337 Sodium fluoride causes hepatocellular S-phase arrest by activating ATM-p53-p21 and ATR-Chk1-Cdc25A pathways in mice.
Kumbhar R et al. Life Sci Alliance 2018; 1 (3):e201800096 Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.
Jones GN et al. Br J Cancer 2018; 119 (10):1233-1243 pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry.
Application : WB
Reactivity : Human
Jin L et al. Cancer Cell 2018; 34 (2):315-330.e7 mast1 drives * resistance in human cancers by rewiring craf-independent mek activation.
Ramhari Kumbhar et al. Life Science Alliance 2018; (Epub) Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling.
Application : WB
Reactivity : Human
Wallez Y et al. Mol Cancer Ther 2018; (Epub) the atr inhibitor azd6738 synergizes with * in vitro and in vivo to induce pancreatic ductal adenocarcinoma regression.
Li Z et al. EMBO J 2018; (Epub) hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.
Application : WB
Reactivity : Human
Zhang J et al. Oncogene 2018; (Epub) BRD4 facilitates replication stress-induced DNA damage response.
Application : WB
Reactivity : Human
Pons M et al. Arch Toxicol 2018; (Epub) Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells.
Application : WB
Reactivity : Human
Sengupta S et al. Mol Cancer Ther 2018; (Epub) Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors.
Application : WB
Reactivity : Human
Limpose KL et al. Nucleic Acids Res 2018; (Epub) Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer.
Application : WB
Reactivity : Human
Goder A et al. Nat Commun 2018; 9 (1):764 HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
Application : WB
Reactivity : Human
Landsverk H.B. et al. bioRxiv 2018; (Epub) Regulation of ATR activity by the RNA polymerase II phosphatase PNUTS-PP1.
Application : WB, IP
Reactivity : Human
Hu L et al. J Immunol 2018; (Epub) TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice.
Reactivity : Mouse
Lin YF et al. Nucleic Acids Res 2018; (Epub) PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway.
Application : WB
Reactivity : Human
Beyaert M et al. Oncotarget 2017; 8 (34):56906-56920 Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function.
Ganaie SS et al. PLoS Pathog 2017; 13 (5):e1006370 Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex.
Xu P et al. PLoS Pathog 2017; 13 (3):e1006266 Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway.
Kemp MG et al. J Biol Chem 2017; 292 (30):12424-12435 DNA damage-induced ATM- and Rad-3-related (ATR) kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor IIH (TFIIH).
Application : WB
Reactivity : Human
Zou W et al. J Virol 2017; (Epub) Human Parvovirus B19 Utilizes Cellular DNA Replication Machinery for Viral DNA Replication.
Hromas R et al. Breast Cancer Res 2017; 19 (1):122 The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells.
Application : WB
Reactivity : Human
Mohr A et al. Cell Death Differ 2017; (Epub) Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment.
Application : WB
Reactivity : Human
Muralidharan SV et al. Cell Death Dis 2017; 8 (8):e2982 BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in melanoma.
Application : WB
Reactivity : Human
Tan SLW et al. Cell 2017; 169 (6):1105-1118.e15 A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.
Application : WB
Reactivity : Human
Iwata T et al. PLoS One 2017; 12 (5):e0178221 The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.
Application : WB
Reactivity : Human
Singh V et al. Cell Cycle 2017;:43112 Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity.
Application : WB
Reactivity : Human
Ashton NW et al. DNA Repair 2017; (Epub) hSSB1 Phosphorylation Is Dynamically Regulated By DNA-PK and PPP-Family Protein Phosphatases.
Application : WB
Reactivity : Human
Williamson CT et al. Nat Commun 2016; 7:13837 ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.
Kanu N et al. Oncogene 2016; 35 (30):4009-19 RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.
Application : WB
Reactivity : Mouse
Fujikane R et al. Scientific Reports 2016; 6:31714 Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis.
Application : WB
Reactivity : Human
Deng X et al. PLoS Pathog 2016; 12 (1):e1005399 Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways.
Application : WB
Reactivity : Human
Wu Y et al. PLoS Genet 2015; 11 (12):e1005675 EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.
Beggs KM et al. Toxicology 2015; 331:35-46 Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related.
Application : WB
Reactivity : Human
Glanzer JG et al. Cancer Res 2014; RPA Inhibition increases Replication Stress and Suppresses Tumor Growth.
Application : WB
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