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ATRX antibody [39f]

Anti-ATRX antibody [39f] used in IHC (Paraffin sections) (IHC-P). GTX34418

Cat No. GTX34418

Host

Mouse

Clonality

Monoclonal

Clone Name

39f

Isotype

IgG1

Application

IHC-P

Reactivity

Human
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1-2μg/ml for 30 minutes at RT

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.

Not tested in other applications.

Calculated MW

283 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA, 0.05% sodium azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full-length human ATRX protein

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ATR2 , ATRX , ATRX, chromatin remodeler , JMS , MRX52 , MRXHF1 , RAD54 , RAD54L , SFM1 , SHS , XH2 , XNP , ZNFHX , ATRX chromatin remodeler

Cellular Localization

Nucleus,Chromosome,Telomere,PML body

Background

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

Database

Research Area

DATA IMAGES

Anti-ATRX antibody [39f] used in IHC (Paraffin sections) (IHC-P). GTX34418

GTX34418 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX34418 ATRX antibody [39f].

REFERENCE

There are currently no references for ATRX antibody [39f] (GTX34418). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for ATRX antibody [39f] (GTX34418). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339