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AVPR2 antibody

Anti-AVPR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13148

Cat No. GTX13148

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human
Package
25 μg ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 3 - 6 μg/ml
Not tested in other applications.

Calculated MW

40.28 kDa. ( Note )

Predict Reactivity

Dog, Monkey, Baboon, Gibbon, Gorilla, Marmoset, Panda(>80% identity)
PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 15 amino acid peptide from C-terminus of human AVPR2.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

ADHR,AVPR2,DI1,DIR,DIR3,NDI,V2R,arginine vasopressin receptor 2,AVP Receptor V2,AVPR V2

Cellular Localization

Cell membrane

Background

This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-AVPR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13148

GTX13148 IHC-P Image

IHC-P analysis of human kidney tissue (renal tubules) using GTX13148 AVPR2 antibody.
Antigen retrival : Heat-induced antigen retrieval

REFERENCE
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Package List Price ($)
$ 319