APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
26 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Bovine, Dog, Pig, Baboon, Bat, Chimpanzee, Elephant, Gibbon, Gorilla, Horse, Marmoset, Orangutan, Panda, Shrew, Armadillo(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human AVPR2.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_375362
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
arginine vasopressin receptor 2 , ADHR , AVPR2 , DI1 , DIR , DIR3 , NDI , V2R , AVP Receptor V2 , AVPR V2
Cellular Localization
Cell membrane
Background
This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX70835 IHC-P Image
IHC-P analysis of human lung, adenocarcinoma tissue using GTX70835 AVPR2 antibody. Antigen retrieval : Heat-induced antigen retrieval
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GTX70835 IHC-P Image
IHC-P analysis of human kidney, renal tubules tissue using GTX70835 AVPR2 antibody. Antigen retrieval : Heat-induced antigen retrieval
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GTX70835 IHC-P Image
IHC-P analysis of human breast, carcinoma tissue using GTX70835 AVPR2 antibody. Antigen retrieval : Heat-induced antigen retrieval
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REFERENCE
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REVIEW
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