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Acetyl-CoA Carboxylase 1 antibody [RM232]

Anti-Acetyl-CoA Carboxylase 1 antibody [RM232] used in Western Blot (WB). GTX33608
Anti-Acetyl-CoA Carboxylase 1 antibody [RM232] used in IHC (Paraffin sections) (IHC-P). GTX33608

Cat No. GTX33608

Host

Rabbit

Clonality

Monoclonal

Clone Name

RM232

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μl ($279)

APPLICATION

Application Note

Immunohistochemistry (IHC): 1:300-1:500 dilution, Western Blot (WB): 1:1000-1:2000 dilution.

Calculated MW

266 kDa. ( Note )

Specificity/Sensitivity

This antibody reacts to human Acetyl CoA Carboxylase 1. This antibody may also react to mouse or rat Acetyl CoA Carboxylase 1, as predicted by immunogen homology.

PROPERTIES

Form

Liquid

Buffer

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A peptide corresponding to human Acetyl CoA Carboxylase 1.

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Acetyl-Coa Carboxylase Alpha , Acac , Acacad , Acc , Acc1 , Acca , Acaca

Background

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Acetyl-CoA Carboxylase 1 antibody [RM232] used in Western Blot (WB). GTX33608

GTX33608 WB Image

Western Blot of A431 cell lysates using Anti-Acetyl CoA Carboxylase 1 RM232 at a 1: 1,000 dilution, showed a band of Acetyl CoA Carboxylase 1 (~260 kDa) expressed in A431 cells.

Anti-Acetyl-CoA Carboxylase 1 antibody [RM232] used in IHC (Paraffin sections) (IHC-P). GTX33608

GTX33608 IHC-P Image

Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer tissue sections using Anti-Acetyl CoA Carboxylase 1 RM232 at a 1:300 dilution.

REFERENCE

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REVIEW

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Package List Price ($)
$ 279