APPLICATION
Application Note
The peptide is used for blocking the antibody activity of Acinus (catalog number GTX27352). Itusually blocks the antibody activity completely in Western blot by incubating the peptide withequal volume of antibody for 30 min at 37ºC
PROPERTIES
Form
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% Sodium azide
Storage
Store the peptide at -20ºC, stable for one year.
Concentration
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
Apoptotic Chromatin Condensation Inducer 1 , Acinus , Acn , Fsap152 , Acin1
Background
Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS.
Research Area
REFERENCE
There are currently no references for Acinus peptide (GTX28367). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Acinus peptide (GTX28367). Be the first to share your experience with this product.