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United States (US)

Actinomycin D (Ready-to-Use)

Cat No. GTX47938

Application

 Cell Culture, Control
Package
50 μl ($149)
See all Actinomycin D products
PRODUCT

Summary

A small molecule that acts as an antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells. A potent inducer of apoptosis in many cell lines

APPLICATION

Application Note

We recommend using 1000X dilutions for inducing apoptosis in Jurkat cells (e.g., Add 1 uL to 1 ml of culture medium). However, the optimal doses may vary for different cells and culture conditions.

PROPERTIES

Form

Liquid

Buffer

In DMSO (10 mM)

Storage

Store at -20ºC. Protect from light and moisture.

Concentration

10 mM (Please refer to the vial label for the specific concentration.)

Purity

>98% pure, as determined by TLC

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Dactinomycin , Apoptosis Inducer , Actinomycin C1 , Actinomycin IV

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Package List Price ($)
$ 149