PRODUCT
Summary
A small molecule that acts as an antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells. A potent inducer of apoptosis in many cell lines
APPLICATION
Application Note
We recommend using 1000X dilutions for inducing apoptosis in Jurkat cells (e.g., Add 1 uL to 1 ml of culture medium). However, the optimal doses may vary for different cells and culture conditions.
PROPERTIES
Form
Liquid
Buffer
10mM DMSO
Preservative
No preservative
Storage
Store at -20ºC. Protect from light and moisture.
Concentration
10 mM (Please refer to the vial label for the specific concentration.)
Purity
>98% pure, as determined by TLC
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
Dactinomycin , Apoptosis Inducer , Actinomycin C1 , Actinomycin IV
REFERENCE
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REVIEW
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